(3R,3‘S,4‘S)-3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4’-hydroxy-[1,3’-bipiperidin]-2-one hydrochloride

Base Information

Chemical Name:(3R,3‘S,4‘S)-3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4’-hydroxy-[1,3’-bipiperidin]-2-one hydrochloride
CAS No.:1510832-33-3
Molecular Formula:C₁₇H₂₁ClF₃N₃O₂*ClH
Molecular Weight:428.282
Hs Code.:

Synonyms:(3R,3‘S,4‘S)-3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4’-hydroxy-[1,3’-bipiperidin]-2-one hydrochloride

Suppliers and Price of (3R,3‘S,4‘S)-3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4’-hydroxy-[1,3’-bipiperidin]-2-one hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,3‘S,4‘S)-3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4’-hydroxy-[1,3’-bipiperidin]-2-one hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,3‘S,4‘S)-3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4’-hydroxy-[1,3’-bipiperidin]-2-one hydrochloride

There total 13 articles about (3R,3‘S,4‘S)-3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4’-hydroxy-[1,3’-bipiperidin]-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68766-96-1
ethyl (R)-2-pyrrolidone-5-carboxylate

: 1510832-33-3
(3R,3‘S,4‘S)-3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4’-hydroxy-[1,3’-bipiperidin]-2-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 40 °C / Inert atmosphere

2: diisobutylaluminium hydride / 2-methyltetrahydrofuran; n-heptane / -45 - -35 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride / dimethyl sulfoxide / 2 h / 45 - 55 °C / Inert atmosphere

4: ethanol / dimethyl sulfoxide

5: hydrogenchloride / isopropyl alcohol; butan-1-ol; water / 17 h / 20 °C / Cooling with ice

With hydrogenchloride; copper(l) iodide; ethanol; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; caesium carbonate; N,N`-dimethylethylenediamine; In 2-methyltetrahydrofuran; 1,4-dioxane; n-heptane; water; dimethyl sulfoxide; isopropyl alcohol; butan-1-ol;

Reference yield:

: 1510832-31-1
(3R,3‘S,4’S)-tert-butyl 3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4'-hydroxy-2-oxo-[1,3'-bipiperidine]-1'-carboxylate

: 1510832-33-3
(3R,3‘S,4‘S)-3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4’-hydroxy-[1,3’-bipiperidin]-2-one hydrochloride

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; butan-1-ol; at 20 ℃; for 17h; Cooling with ice;

Reference yield:

: 1510866-72-4
(3S,4S)-3-aminopiperidin-4-ol

: 1510832-33-3
(3R,3‘S,4‘S)-3-((3-chloro-5-(trifluoromethyl)phenyl)amino)-4’-hydroxy-[1,3’-bipiperidin]-2-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 12 h

2: triethylamine / tetrahydrofuran / 4 h / 20 °C

3: sodium tris(acetoxy)borohydride / dimethyl sulfoxide / 2 h / 45 - 55 °C / Inert atmosphere

4: ethanol / dimethyl sulfoxide

5: hydrogenchloride / isopropyl alcohol; butan-1-ol; water / 17 h / 20 °C / Cooling with ice

With hydrogenchloride; ethanol; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; water; dimethyl sulfoxide; isopropyl alcohol; butan-1-ol;