N-((1R,2S)-2-{[tert-butoxycarbonyl[3-(4-fluorophenyl)propyl]amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Base Information

Chemical Name:N-((1R,2S)-2-{[tert-butoxycarbonyl[3-(4-fluorophenyl)propyl]amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea
CAS No.:852660-37-8
Molecular Formula:C₃₀H₄₀FN₇O₃
Molecular Weight:565.691
Hs Code.:

Synonyms:N-((1R,2S)-2-{[tert-butoxycarbonyl[3-(4-fluorophenyl)propyl]amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

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Chemical Property of N-((1R,2S)-2-{[tert-butoxycarbonyl[3-(4-fluorophenyl)propyl]amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

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Technology Process of N-((1R,2S)-2-{[tert-butoxycarbonyl[3-(4-fluorophenyl)propyl]amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

There total 16 articles about N-((1R,2S)-2-{[tert-butoxycarbonyl[3-(4-fluorophenyl)propyl]amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852660-36-7
(1R,2S)-2-({tert-butoxycarbonyl-[3-(4-fluorophenyl)-propyl]amino}-methyl)-cyclohexylamine

: 382637-78-7
[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-carbamic acid phenyl ester

: 852660-37-8
N-((1R,2S)-2-{[tert-butoxycarbonyl[3-(4-fluorophenyl)propyl]amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 7116-38-3
ethyl 3-(4-fluorophenyl)propanoate

: 852660-37-8
N-((1R,2S)-2-{[tert-butoxycarbonyl[3-(4-fluorophenyl)propyl]amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; water / methanol / Heating / reflux

1.2: pH 1

2.1: thionyl chloride / dichloromethane / 24 h / 25 °C

3.1: ammonia / tetrahydrofuran; water / 2 h / 0 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C

6.1: tetrahydrofuran

7.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr

8.1: N,N-dimethyl-formamide / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonia; water; hydrogen; sodium tris(acetoxy)borohydride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 136265-10-6,352-03-4,24393-50-8
ethyl 4-fluorocinnamate

: 852660-37-8
N-((1R,2S)-2-{[tert-butoxycarbonyl[3-(4-fluorophenyl)propyl]amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

2.1: sodium hydroxide; water / methanol / Heating / reflux

2.2: pH 1

3.1: borane-THF / tetrahydrofuran / 25 °C / Heating / reflux

4.1: pyridine / 168 h / 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr

7.1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C

8.1: tetrahydrofuran

9.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr

10.1: N,N-dimethyl-formamide / 20 °C

With pyridine; sodium hydroxide; sodium azide; borane-THF; water; hydrogen; sodium tris(acetoxy)borohydride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;