(1R,2S)-2-({tert-butoxycarbonyl-[3-(4-fluorophenyl)-propyl]amino}-methyl)-cyclohexylamine

Base Information

Chemical Name:(1R,2S)-2-({tert-butoxycarbonyl-[3-(4-fluorophenyl)-propyl]amino}-methyl)-cyclohexylamine
CAS No.:852660-36-7
Molecular Formula:C₂₁H₃₃FN₂O₂
Molecular Weight:364.504
Hs Code.:

Synonyms:(1R,2S)-2-({tert-butoxycarbonyl-[3-(4-fluorophenyl)-propyl]amino}-methyl)-cyclohexylamine

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Chemical Property of (1R,2S)-2-({tert-butoxycarbonyl-[3-(4-fluorophenyl)-propyl]amino}-methyl)-cyclohexylamine

Chemical Property:

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Technology Process of (1R,2S)-2-({tert-butoxycarbonyl-[3-(4-fluorophenyl)-propyl]amino}-methyl)-cyclohexylamine

There total 15 articles about (1R,2S)-2-({tert-butoxycarbonyl-[3-(4-fluorophenyl)-propyl]amino}-methyl)-cyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852660-35-6
(1R,2S)-[2-({tert-butoxycarbonyl-[3-(4-fluoro-phenyl)-propyl]amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester

: 852660-36-7
(1R,2S)-2-({tert-butoxycarbonyl-[3-(4-fluorophenyl)-propyl]amino}-methyl)-cyclohexylamine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; under 2585.81 Torr;

Reference yield:

: 7116-38-3
ethyl 3-(4-fluorophenyl)propanoate

: 852660-36-7
(1R,2S)-2-({tert-butoxycarbonyl-[3-(4-fluorophenyl)-propyl]amino}-methyl)-cyclohexylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide; water / methanol / Heating / reflux

1.2: pH 1

2.1: thionyl chloride / dichloromethane / 24 h / 25 °C

3.1: ammonia / tetrahydrofuran; water / 2 h / 0 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C

6.1: tetrahydrofuran

7.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonia; water; hydrogen; sodium tris(acetoxy)borohydride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 136265-10-6,352-03-4,24393-50-8
ethyl 4-fluorocinnamate

: 852660-36-7
(1R,2S)-2-({tert-butoxycarbonyl-[3-(4-fluorophenyl)-propyl]amino}-methyl)-cyclohexylamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

2.1: sodium hydroxide; water / methanol / Heating / reflux

2.2: pH 1

3.1: thionyl chloride / dichloromethane / 24 h / 25 °C

4.1: ammonia / tetrahydrofuran; water / 2 h / 0 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

6.1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C

7.1: tetrahydrofuran

8.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonia; water; hydrogen; sodium tris(acetoxy)borohydride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;