ethyl 3-(4-(3-(trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-yl)acrylate

Base Information

Chemical Name:ethyl 3-(4-(3-(trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-yl)acrylate
CAS No.:1356465-37-6
Molecular Formula:C₁₇H₁₉F₃O₃
Molecular Weight:328.331
Hs Code.:

Synonyms:ethyl 3-(4-(3-(trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-yl)acrylate

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Chemical Property of ethyl 3-(4-(3-(trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-yl)acrylate

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Technology Process of ethyl 3-(4-(3-(trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-yl)acrylate

There total 3 articles about ethyl 3-(4-(3-(trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 902836-56-0
4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbaldehyde

: 141-78-6
ethyl acetate

: 1356465-37-6
ethyl 3-(4-(3-(trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-yl)acrylate

Guidance literature:: 4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbaldehyde; With diethoxyphosphoryl-acetic acid ethyl ester; N-ethyl-N,N-diisopropylamine; lithium bromide; In tetrahydrofuran; at 20 ℃; for 16h;

ethyl acetate; With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 2338-76-3
3-trifluoromethylphenylacetonitrile

: 1356465-37-6
ethyl 3-(4-(3-(trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C / Cooling with ice

1.2: 2 h / 20 °C

2.1: hydrogenchloride; diisobutylaluminium hydride / toluene; water / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; diethoxyphosphoryl-acetic acid ethyl ester; lithium bromide / tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; diethoxyphosphoryl-acetic acid ethyl ester; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium bromide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1035261-83-6
4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonitrile

: 1356465-37-6
ethyl 3-(4-(3-(trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; diisobutylaluminium hydride / toluene; water / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; diethoxyphosphoryl-acetic acid ethyl ester; lithium bromide / tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; diethoxyphosphoryl-acetic acid ethyl ester; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium bromide; In tetrahydrofuran; water; toluene;