(2S,4R)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carbonitrile

Base Information

Chemical Name:(2S,4R)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carbonitrile
CAS No.:1448667-89-7
Molecular Formula:C₃₀H₂₉N₃O
Molecular Weight:447.58
Hs Code.:

Synonyms:(2S,4R)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carbonitrile

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Chemical Property of (2S,4R)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of (2S,4R)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carbonitrile

There total 11 articles about (2S,4R)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448667-88-6
(2S,4R)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carboxamide

: 1448667-89-7
(2S,4R)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carbonitrile

Guidance literature:: With trifluoromethylsulfonic anhydride; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 1871-76-7
diphenylacetic acid chloride

: 1448667-89-7
(2S,4R)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 0.25 h / 0 °C

2.1: 10% palladium hydroxide on charcoal; hydrogen / isopropyl alcohol / 30 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 35 °C

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

5.1: HATU; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 20 °C

6.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; trifluoromethylsulfonic anhydride; 10% palladium hydroxide on charcoal; water; hydrogen; caesium carbonate; triethylamine; HATU; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1799811-83-8
1-(tert-butyl)-2-methyl-(S)-4-oxopiperidine-1,2-dicarboxylate

: 1448667-89-7
(2S,4R)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / methanol / 1 h / 20 °C

1.2: 0 - 20 °C

2.1: hydrogenchloride / methanol / 20 °C

3.1: triethylamine / dichloromethane / 0.25 h / 0 °C

4.1: 10% palladium hydroxide on charcoal; hydrogen / isopropyl alcohol / 30 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 35 °C

6.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

7.1: HATU; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

7.2: 20 °C

8.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; lithium hydroxide monohydrate; trifluoromethylsulfonic anhydride; 10% palladium hydroxide on charcoal; water; hydrogen; caesium carbonate; acetic acid; triethylamine; HATU; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;