((2S,4R)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)-2-(1H-tetrazol-5-yl)piperidin-1-yl)-2,2-diphenylethanone

Base Information

Chemical Name:((2S,4R)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)-2-(1H-tetrazol-5-yl)piperidin-1-yl)-2,2-diphenylethanone
CAS No.:1448667-90-0
Molecular Formula:C₃₀H₃₀N₆O
Molecular Weight:490.608
Hs Code.:

Synonyms:((2S,4R)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)-2-(1H-tetrazol-5-yl)piperidin-1-yl)-2,2-diphenylethanone

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Chemical Property of ((2S,4R)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)-2-(1H-tetrazol-5-yl)piperidin-1-yl)-2,2-diphenylethanone

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Technology Process of ((2S,4R)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)-2-(1H-tetrazol-5-yl)piperidin-1-yl)-2,2-diphenylethanone

There total 11 articles about ((2S,4R)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)-2-(1H-tetrazol-5-yl)piperidin-1-yl)-2,2-diphenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1448667-89-7
(2S,4R)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carbonitrile

: 1448667-90-0
((2S,4R)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)-2-(1H-tetrazol-5-yl)piperidin-1-yl)-2,2-diphenylethanone

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 100 ℃; Sealed tube;

Reference yield:

: 1871-76-7
diphenylacetic acid chloride

: 1448667-90-0
((2S,4R)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)-2-(1H-tetrazol-5-yl)piperidin-1-yl)-2,2-diphenylethanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0.25 h / 0 °C

2.1: 10% palladium hydroxide on charcoal; hydrogen / isopropyl alcohol / 30 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 35 °C

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

5.1: HATU; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 20 °C

6.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: ammonium chloride; sodium azide / N,N-dimethyl-formamide / 100 °C / Sealed tube

With sodium azide; lithium hydroxide monohydrate; trifluoromethylsulfonic anhydride; 10% palladium hydroxide on charcoal; water; hydrogen; ammonium chloride; caesium carbonate; triethylamine; HATU; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1799811-83-8
1-(tert-butyl)-2-methyl-(S)-4-oxopiperidine-1,2-dicarboxylate

: 1448667-90-0
((2S,4R)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)-2-(1H-tetrazol-5-yl)piperidin-1-yl)-2,2-diphenylethanone

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid / methanol / 1 h / 20 °C

1.2: 0 - 20 °C

2.1: hydrogenchloride / methanol / 20 °C

3.1: triethylamine / dichloromethane / 0.25 h / 0 °C

4.1: 10% palladium hydroxide on charcoal; hydrogen / isopropyl alcohol / 30 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 35 °C

6.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

7.1: HATU; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

7.2: 20 °C

8.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

9.1: ammonium chloride; sodium azide / N,N-dimethyl-formamide / 100 °C / Sealed tube

With hydrogenchloride; sodium azide; lithium hydroxide monohydrate; trifluoromethylsulfonic anhydride; 10% palladium hydroxide on charcoal; water; hydrogen; ammonium chloride; caesium carbonate; acetic acid; triethylamine; HATU; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;