methyl 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylate

Base Information

Chemical Name:methyl 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylate
CAS No.:1549953-19-6
Molecular Formula:C₂₉H₃₃F₆NO₃
Molecular Weight:557.576
Hs Code.:

Synonyms:methyl 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylate

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Chemical Property of methyl 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylate

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Technology Process of methyl 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylate

There total 7 articles about methyl 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427386-78-4
9-aza-bicyclo[3.3.1]nonane-3-carboxylic acid methyl ester hydrochloride

: 1544662-71-6
5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthaldehyde

: 1549953-19-6
methyl 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylate

Guidance literature:: 9-aza-bicyclo[3.3.1]nonane-3-carboxylic acid methyl ester hydrochloride; With triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 0.333333h;

5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthaldehyde; In 1,2-dichloro-ethane; at 50 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 1266120-65-3
4-(trifluoromethyl)cyclohexyl methanesulfonate

: 1549953-19-6
methyl 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 85 °C

2.1: ISCO column chromatography / Resolution of racemate

3.1: N-iodo-succinimide; zirconium(IV) chloride / dichloromethane / 20 °C

4.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere

5.1: triethylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C

5.2: 1 h / 50 °C

5.3: 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; zirconium(IV) chloride; caesium carbonate; triethylamine; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1309977-21-6
6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthaldehyde

: 1549953-19-6
methyl 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-iodo-succinimide; zirconium(IV) chloride / dichloromethane / 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere

3.1: triethylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C

3.2: 1 h / 50 °C

3.3: 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; zirconium(IV) chloride; triethylamine; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;