9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid trifluoroacetate

Base Information

Chemical Name:9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid trifluoroacetate
CAS No.:1549947-21-8
Molecular Formula:C₂HF₃O₂*C₂₈H₃₁F₆NO₃
Molecular Weight:657.573
Hs Code.:

9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid trifluoroacetate

Synonyms:9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid trifluoroacetate

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Chemical Property of 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid trifluoroacetate

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Technology Process of 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid trifluoroacetate

There total 8 articles about 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1549953-19-6
methyl 9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylate

: 1549947-21-8
9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid trifluoroacetate

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 1266120-65-3
4-(trifluoromethyl)cyclohexyl methanesulfonate

: 1549947-21-8
9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 85 °C

2.1: ISCO column chromatography / Resolution of racemate

3.1: N-iodo-succinimide; zirconium(IV) chloride / dichloromethane / 20 °C

4.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere

5.1: triethylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C

5.2: 1 h / 50 °C

5.3: 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; water; zirconium(IV) chloride; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 75091-92-8,75091-93-9,30129-18-1
4-(trifluoromethyl)cyclohexan-1-ol

: 1549947-21-8
9-((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 85 °C

3.1: ISCO column chromatography / Resolution of racemate

4.1: N-iodo-succinimide; zirconium(IV) chloride / dichloromethane / 20 °C

5.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere

6.1: triethylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C

6.2: 1 h / 50 °C

6.3: 20 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; water; zirconium(IV) chloride; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;