(R,E)-N-(1-phenylethyl)-1-(pyridin-2-yl)methanimine

Base Information

• Chemical Name: (R,E)-N-(1-phenylethyl)-1-(pyridin-2-yl)methanimine
• CAS No.: 38010-70-7
• Molecular Formula: C₁₄H₁₄N₂
• Molecular Weight: 210.279
• Mol file: 38010-70-7.mol

Synonyms:(R,E)-N-(1-phenylethyl)-1-(pyridin-2-yl)methanimine

Chemical Property of (R,E)-N-(1-phenylethyl)-1-(pyridin-2-yl)methanimine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R,E)-N-(1-phenylethyl)-1-(pyridin-2-yl)methanimine

There total 2 articles about (R,E)-N-(1-phenylethyl)-1-(pyridin-2-yl)methanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyridine-2-carbaldehyde (1121-60-4) + (R)-1-phenyl-ethyl-amine (3886-69-9) → (R,E)-N-(1-phenylethyl)-1-(pyridin-2-yl)methanimine (38010-70-7)

Guidance literature:

In toluene; Reflux; Inert atmosphere; Dean-Stark;

DOI:10.1021/acs.organomet.0c00703

Reference yield: 98.0%

pyridine-2-carbaldehyde (1121-60-4) + (S)-1-phenyl-ethylamine (2627-86-3) → (S)-1-phenyl-N-[(pyridin-2-yl)methylene]ethanamine (38010-70-7,40468-87-9,51705-23-8,57707-75-2,76739-45-2,95341-88-1,125875-26-5)

Guidance literature:

With sodium sulfate; In diethyl ether; for 24h; Ambient temperature;

DOI:10.1016/0022-328X(92)83336-G

Reference yield: 95.0%

methyl but-3-enoate (3724-55-8) + (R,E)-N-(1-phenylethyl)-1-(pyridin-2-yl)methanimine (38010-70-7) → Methyl (E)-5-<(R)-<(1-phenylethyl)amino>>-5-(2-pyridyl)-2-pentenoate

Guidance literature:

With zinc(II) chloride; lithium diisopropyl amide; 1.) THF, hexane, -78 deg C, 10 min; Et₂O, -78 deg C, 10 min, 2.) -78 deg C, 1 h;

DOI:10.1021/jo00104a048

upstream raw materials:

pyridine-2-carbaldehyde

(S)-1-phenyl-ethylamine

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

N-[(S)-1-phenylethyl]-N-[1-(2-pyridinyl)methyl]amine

(E)-3-(pyridin-2-yl)prop-2-enoic acid methyl ester

Refernces

• 1、 Akiri, Saphan O.,Ngcobo, Nondumiso L.,Ogweno, Aloice O.,Ojwach, Stephen O.. "Structural elucidation of chiral (imino)pyridine/phosphine palladium(II) complexes and their applications as catalysts in methoxycarbonylation of styrene". . . Retrieved 2021/06/15.
• 2、 Large, Benjamin,Meddeb, Maissa,Pucheta, José Enrique Herbert,Gaucher, Anne,Cordier, Marie,Gosmini, Corinne,Farjon, Jonathan,Auffrant, Audrey,Prim, Damien. "Deciphering preferred geometries of pyridylmethylamines-based complexes: A robust strategy combining NMR, DFT and X-ray". supporting information. . Retrieved 2019/09/09.