Chemical Property of N-Hydroxy-5-norbornene-2,3-dicarboximide
Chemical Property:
- Appearance/Colour:white to off-white crystalline powder
- Vapor Pressure:0mmHg at 25°C
- Melting Point:165-170 °C(lit.)
- Refractive Index:1.673
- Boiling Point:347.7 °C at 760 mmHg
- PKA:9.00±0.20(Predicted)
- Flash Point:164.1 °C
- PSA：57.61000
- Density:1.574 g/cm3
- LogP:0.12060
- Storage Temp.:Store at RT.
- Solubility.:Soluble in ethanol
- XLogP3:-0.2
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:0
- Exact Mass:179.058243149
- Heavy Atom Count:13
- Complexity:306
- Purity/Quality:
-
99%min *data from raw suppliers
N-Hydroxy-5-norbornene-2,3-dicarboximide *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1C2C=CC1C3C2C(=O)N(C3=O)O
-
Description
N-Hydroxy-5-norbornene-2,3-dicarboximide (NHD) is a compound that has
antiviral activity and is used to treat HIV infections. It inhibits the
reverse transcriptase enzyme in the virus, which blocks the synthesis of
viral DNA. The ferroelectric properties of NHD were first observed by
observing changes in its melting point when mixed with water. This
property makes it useful for diagnosis purposes. In animal studies, a
dose of 5 mg/kg was found to be effective against cancer cells and the
drug showed no toxicity in humans at doses up to 500 mg/day. The optimal
reaction conditions for NHD are pH 6 and temperature 45 degrees
Celsius.
-
Uses
N-Hydroxy-5-norbornene-2,3-dicarboximide(HONB) is used in solution-phase peptide synthesis. Used in the synthesis of enkephalin analogs. Inhibits racemization in peptide synthesis using DCC as condensing agent. It decreases racemization in peptide synthesis and inhibits formation of N-acylureas.
