(S,E)-1-(4’-(benzenesulfoxy)phenyl)-3-(tertbutyldimethyl)silyloxyhept-5-ene

Base Information

Chemical Name:(S,E)-1-(4’-(benzenesulfoxy)phenyl)-3-(tertbutyldimethyl)silyloxyhept-5-ene
CAS No.:1429416-48-7
Molecular Formula:C₂₅H₃₆O₄SSi
Molecular Weight:460.71
Hs Code.:

Synonyms:(S,E)-1-(4’-(benzenesulfoxy)phenyl)-3-(tertbutyldimethyl)silyloxyhept-5-ene

Suppliers and Price of (S,E)-1-(4’-(benzenesulfoxy)phenyl)-3-(tertbutyldimethyl)silyloxyhept-5-ene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,E)-1-(4’-(benzenesulfoxy)phenyl)-3-(tertbutyldimethyl)silyloxyhept-5-ene

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Technology Process of (S,E)-1-(4’-(benzenesulfoxy)phenyl)-3-(tertbutyldimethyl)silyloxyhept-5-ene

There total 5 articles about (S,E)-1-(4’-(benzenesulfoxy)phenyl)-3-(tertbutyldimethyl)silyloxyhept-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1429416-47-6
(S,E)-1-(4’-benzenesulfoxyphenyl)hept-5-en-3-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1429416-48-7
(S,E)-1-(4’-(benzenesulfoxy)phenyl)-3-(tertbutyldimethyl)silyloxyhept-5-ene

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; for 40h; Inert atmosphere;
DOI:10.1021/ol400736w

Reference yield:

: 31770-76-0
3-(4-hydroxyphenyl)propionic acid benzyl ester

: 1429416-48-7
(S,E)-1-(4’-(benzenesulfoxy)phenyl)-3-(tertbutyldimethyl)silyloxyhept-5-ene

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / dichloromethane; hexane / 6 h / -78 °C / Inert atmosphere

3: toluene-4-sulfonic acid / dichloromethane / 20 h / Inert atmosphere

4: 1H-imidazole; dmap / dichloromethane / 40 h / Inert atmosphere

With 1H-imidazole; dmap; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; In hexane; dichloromethane;
DOI:10.1021/ol400736w

Reference yield:

: benzyl 3-(4’-benzenesulfoxyphenyl)propionate

: 1429416-48-7
(S,E)-1-(4’-(benzenesulfoxy)phenyl)-3-(tertbutyldimethyl)silyloxyhept-5-ene

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane; hexane / 6 h / -78 °C / Inert atmosphere

2: toluene-4-sulfonic acid / dichloromethane / 20 h / Inert atmosphere

3: 1H-imidazole; dmap / dichloromethane / 40 h / Inert atmosphere

With 1H-imidazole; dmap; diisobutylaluminium hydride; toluene-4-sulfonic acid; In hexane; dichloromethane;
DOI:10.1021/ol400736w