bis-(3,7-dimethyl-octa-2,6-dienyl)-malonic acid diethyl ester

Base Information

• Chemical Name: bis-(3,7-dimethyl-octa-2,6-dienyl)-malonic acid diethyl ester
• CAS No.: 16725-62-5
• Molecular Formula: C₂₇H₄₄O₄
• Molecular Weight: 432.644
• Mol file: 16725-62-5.mol

Synonyms:bis-(3,7-dimethyl-octa-2,6-dienyl)-malonic acid diethyl ester

Chemical Property of bis-(3,7-dimethyl-octa-2,6-dienyl)-malonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of bis-(3,7-dimethyl-octa-2,6-dienyl)-malonic acid diethyl ester

There total 3 articles about bis-(3,7-dimethyl-octa-2,6-dienyl)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Geraniol (106-24-1) + lithium diethyl malonate (34727-00-9) → bis-(3,7-dimethyl-octa-2,6-dienyl)-malonic acid diethyl ester (16725-62-5) + diethyl [(2E)-3,7-dimethylocta-2,6-dienyl]malonate (19894-79-2)

Guidance literature:

With n-butyllithium; triphenylborane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, r.t., 5 min; 2.) r.t., 10 min; 3.) THF, reflux, 3 h;

DOI:10.1016/S0040-4020(01)80774-2

Reference yield:

trans-geranyl bromide (6138-90-5) + diethyl malonate (105-53-3) → bis-(3,7-dimethyl-octa-2,6-dienyl)-malonic acid diethyl ester (16725-62-5) + diethyl [(2E)-3,7-dimethylocta-2,6-dienyl]malonate (19894-79-2)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) DMF, RT, 20 min, 2.) DMF, THF, from -10 deg C to RT, 2.5 h;

DOI:10.1246/bcsj.54.3530

Reference yield:

Geraniol (106-24-1) + lithium diethyl malonate (34727-00-9) → biphenyl (92-52-4,1594-86-1) + bis-(3,7-dimethyl-octa-2,6-dienyl)-malonic acid diethyl ester (16725-62-5) + diethyl [(2E)-3,7-dimethylocta-2,6-dienyl]malonate (19894-79-2) + phenol (108-95-2,27073-41-2)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1016/S0040-4039(00)60088-6

upstream raw materials:

Geraniol

lithium diethyl malonate

trans-geranyl bromide

diethyl malonate