N--L-alanyl>-(4R)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

Base Information

Chemical Name:N--L-alanyl>-(4R)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester
CAS No.:126257-67-8
Molecular Formula:C₂₇H₄₀N₂O₈
Molecular Weight:520.623
Hs Code.:

N-<N'-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-L-alanyl>-(4R)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

Synonyms:N--L-alanyl>-(4R)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

Suppliers and Price of N--L-alanyl>-(4R)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N--L-alanyl>-(4R)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N--L-alanyl>-(4R)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

There total 3 articles about N--L-alanyl>-(4R)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18742-02-4
2-bromo-2-(2-ethyl)dioxolane

: 126257-67-8
N--L-alanyl>-(4R)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / NaI / acetone / 0.5 h / Heating

2: 14 percent / silver oxide / dimethylformamide / 1.) 25 deg C, 18 h, 2.) 45 deg C, 5 h

3: 2.49 g / H₂, Et₃N / 10percent Pd/C / 3 h / 2068.6 Torr

4: 1.) 1,1-carbonyldiimidazole / 1.) CH₂Cl₂, from 0 to 5 deg C, 30 min, 2.) 25 deg C, overnight

With hydrogen; triethylamine; 1,1'-carbonyldiimidazole; sodium iodide; silver(l) oxide; palladium on activated charcoal; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00168a013

Reference yield:

: 83665-55-8
2-(2-iodoethyl)-1,3-dioxolane

: 126257-67-8
N--L-alanyl>-(4R)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 14 percent / silver oxide / dimethylformamide / 1.) 25 deg C, 18 h, 2.) 45 deg C, 5 h

2: 2.49 g / H₂, Et₃N / 10percent Pd/C / 3 h / 2068.6 Torr

3: 1.) 1,1-carbonyldiimidazole / 1.) CH₂Cl₂, from 0 to 5 deg C, 30 min, 2.) 25 deg C, overnight

With hydrogen; triethylamine; 1,1'-carbonyldiimidazole; silver(l) oxide; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1021/jm00168a013

Reference yield:

: 126257-65-6
(4R)-N-(carbobenzyloxy)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

: 126257-67-8
N--L-alanyl>-(4R)-4-<3-(1,3-dioxolan-2-yl)propoxy>-L-proline ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2.49 g / H₂, Et₃N / 10percent Pd/C / 3 h / 2068.6 Torr

2: 1.) 1,1-carbonyldiimidazole / 1.) CH₂Cl₂, from 0 to 5 deg C, 30 min, 2.) 25 deg C, overnight

With hydrogen; triethylamine; 1,1'-carbonyldiimidazole; palladium on activated charcoal;
DOI:10.1021/jm00168a013