2,2-Dimethyl-propionic acid (R)-2-benzyloxycarbonylamino-2-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-6,4',6'-trimethoxy-biphenyl-3-yl]-ethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (R)-2-benzyloxycarbonylamino-2-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-6,4',6'-trimethoxy-biphenyl-3-yl]-ethyl ester
CAS No.:292865-37-3
Molecular Formula:C₃₅H₄₂N₂O₈
Molecular Weight:618.727
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (R)-2-benzyloxycarbonylamino-2-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-6,4',6'-trimethoxy-biphenyl-3-yl]-ethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (R)-2-benzyloxycarbonylamino-2-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-6,4',6'-trimethoxy-biphenyl-3-yl]-ethyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (R)-2-benzyloxycarbonylamino-2-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-6,4',6'-trimethoxy-biphenyl-3-yl]-ethyl ester

There total 11 articles about 2,2-Dimethyl-propionic acid (R)-2-benzyloxycarbonylamino-2-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-6,4',6'-trimethoxy-biphenyl-3-yl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 292865-36-2
2,2-Dimethyl-propionic acid (R)-2-amino-2-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-6,4',6'-trimethoxy-biphenyl-3-yl]-ethyl ester

: 292865-37-3
2,2-Dimethyl-propionic acid (R)-2-benzyloxycarbonylamino-2-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-6,4',6'-trimethoxy-biphenyl-3-yl]-ethyl ester

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 2h;
DOI:10.1021/ol006110s

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: 292865-37-3
2,2-Dimethyl-propionic acid (R)-2-benzyloxycarbonylamino-2-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-6,4',6'-trimethoxy-biphenyl-3-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: SOCl₂

2.1: NaHCO₃ / CHCl₃

3.1: 87 percent / Br₂ / CHCl₃

4.1: 95 percent / LiAlH₄ / tetrahydrofuran

5.1: 97 percent / K₂CO₃ / dimethylformamide

6.1: 85 percent / SOCl₂

7.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h / Heating

7.2: 87 percent / tetrahydrofuran / 15 h / Heating

8.1: TFA / methanol / 2 h / 20 °C

9.1: 680 mg / NaHCO₃ / dioxane; H₂O / 2 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; bromine; sodium hydrogencarbonate; potassium carbonate; magnesium; ethylene dibromide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide; 1.1: Esterification / 2.1: Acylation / 3.1: Bromination / 4.1: Reduction / 5.1: Methylation / 6.1: Cyclization / 7.1: Metallation / 7.2: Substitution / 8.1: Ring cleavage / 9.1: Substitution;
DOI:10.1021/ol006110s

Reference yield:

: 37763-23-8
D-2-p-hydroxyphenylglycine methyl ester

: 292865-37-3
2,2-Dimethyl-propionic acid (R)-2-benzyloxycarbonylamino-2-[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-6,4',6'-trimethoxy-biphenyl-3-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaHCO₃ / CHCl₃

2.1: 87 percent / Br₂ / CHCl₃

3.1: 95 percent / LiAlH₄ / tetrahydrofuran

4.1: 97 percent / K₂CO₃ / dimethylformamide

5.1: 85 percent / SOCl₂

6.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h / Heating

6.2: 87 percent / tetrahydrofuran / 15 h / Heating

7.1: TFA / methanol / 2 h / 20 °C

8.1: 680 mg / NaHCO₃ / dioxane; H₂O / 2 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; bromine; sodium hydrogencarbonate; potassium carbonate; magnesium; ethylene dibromide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide; 1.1: Acylation / 2.1: Bromination / 3.1: Reduction / 4.1: Methylation / 5.1: Cyclization / 6.1: Metallation / 6.2: Substitution / 7.1: Ring cleavage / 8.1: Substitution;
DOI:10.1021/ol006110s