37763-23-8

Basic information

• Product Name: Methyl D-(-)-4-hydroxy-phenylglycinate
• Synonyms: D-(-)-alpha-p-Hydroxy-phenylglycine methyl ester;METHYL D-(-)-4-HYDROXY-PHENYLGLYCINATE;methyl (R)-amino(4-hydroxyphenyl)acetate;D-(-)-|á-P-HYDROXY PHENYLGLYCINE METHYL ESTER;(R)-Amino(4-hydroxyphenyl)acetic acid methyl ester;(R)-α-(p-Hydroxyphenyl)glycine methyl ester;4-Hydroxy-D-phenylglycine methyl ester;D-4-Hydroxyphenylglycine methyl ester
• CAS NO: 37763-23-8
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.19
• EINECS: 253-657-2
• Product Categories: Antidote / Antibiotic / Antimicrobial
• Mol File: 37763-23-8.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 335.7 °C at 760 mmHg
• Flash Point: 156.9 °C
• Appearance: /
• Density: 1.248 g/cm³
• Vapor Pressure: 6.03E-05mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Room Temperature
• Solubility: DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
• PKA: 9.74±0.26(Predicted)
• CAS DataBase Reference: Methyl D-(-)-4-hydroxy-phenylglycinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl D-(-)-4-hydroxy-phenylglycinate(37763-23-8)
• EPA Substance Registry System: Methyl D-(-)-4-hydroxy-phenylglycinate(37763-23-8)

Safety Data

• Hazardous Substances Data: 37763-23-8(Hazardous Substances Data)

Usage

Uses

Methyl D-(-)-4-Hydroxy-phenylglycinate is useful for the synthesis (+)-radicamine B. Also, it is used for the preparation of amoxicillin.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C9H11NO3/c1-6(9(12)13-10)7-2-4-8(11)5-3-7/h2-6,11H,10H2,1H3

Upstream product

• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 43189-12-4 (R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate 
• 38177-33-2 (4-acetoxyphenyl)acetic acid 
• 65448-20-6 4-acetoxyphenylacetyl chloride 
• 67-56-1 methanol 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 1327277-97-3 4-(((S)-2-hydroxy-1-phenylethylcarbamoyl)methyl)phenyl acetate 
• 1327278-09-0 4-((S)-5,6-dihydro-2-oxo-5-phenyl-2H-1,4-oxazin-3-yl)phenyl acetate 
• 1327278-02-3 4-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)phenyl acetate 
• 1327278-14-7 4-((3R,5S)-2-oxo-5-phenyl-morpholin-3-yl)phenyl acetate 

Downstream Products

• 38250-16-7 4-hydroxy-alpha-oxobenzeneacetic acid methyl ester 
• 287407-57-2 (R)-methyl 2-(fluorenylmethoxycarbonyl)amino-2-(4-hydroxyphenyl)-acetic acid methyl ester 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 121412-77-9 cefprozil 
• 50370-12-2 cefadroxil 
• 292865-32-8 (R)-(2,2-Dimethyl-propionylamino)-(4-hydroxy-phenyl)-acetic acid methyl ester 
• 143323-49-3 (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate 
• 121666-46-4 (R)-{(1R,2S,4S)-1-[(Dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yloxycarbonylamino}-(4-methoxy-phenyl)-acetic acid methyl ester 
• 123238-81-3 (4R,6R,7S)-7-[(R)-2-Amino-2-(4-hydroxy-phenyl)-acetylamino]-4-methyl-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 72366-92-8 (4S,6R,7S)-7-[(R)-2-Amino-2-(4-hydroxy-phenyl)-acetylamino]-4-methyl-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 72366-97-3 (6R,7S)-7-[(R)-2-Amino-2-(4-hydroxy-phenyl)-acetylamino]-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 76609-94-4 (6R,7S)-7-[(R)-2-Amino-2-(4-hydroxy-phenyl)-acetylamino]-3-chloro-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 26787-78-0 amoxicillin 
• 92665-29-7 7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-(propen-1-yl)-3-cephem-4-carboxylic acid 

Relevant articles and documents

A COMPOUND FOR THE DETERMINATION OF THE PROTEIN FKBP12 AND A SENSOR UNIT COMPRISING IT

The present invention relates to novel compounds useful as sensors for the rapid and specific determination of the FKBP12 protein, a peptidyl-prolyl cis-trans isomerase (PPlase), the levels of which in the biological fluids of a subject change if the subject is affected by pathological conditions, in particular neurodegenerative diseases, such as the Parkinson's disease and the Alzheimer's syndrome, tumour pathologies, autoimmune diseases, or if that subject is in a phase of acute rejection after organ transplantation.

Stereoselective total synthesis of (+)-radicamine B via anti,syn,syn-oxazine

The stereoselective total synthesis of (+)-radicamine B was achieved using commercially available D-4-hydroxy-phenylglycine via chiral 1,3-oxazine, which has been applied to synthesis of amino polyols such as DAB-1, D-fagomine, and phytosphingosines. The key steps in this strategy were the palladium(0)-catalyzed stereoselective intramolecular oxazine formation, an extension of the chirality of anti,syn-oxazine with Lewis acid and vinylmagnesium bromide, and pyrrolidine ring formation via hydrogenation reaction. The chiral extension is also applicable to other chiral 1,3-oxazine derived from D-4-hydroxy-phenylglycine.

HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS

The invention provides compounds of formula I: (I) or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing com-pounds of formula I, intermediates useful for preparing com-pounds of formula I and therapeutic methods for suppressing an immune response or treating cancer, including a hematologic malignancy, using compounds of formula I