(3-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester

Base Information

Chemical Name:(3-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester
CAS No.:927187-47-1
Molecular Formula:C₂₇H₂₂Cl₂N₂O₅
Molecular Weight:525.388
Hs Code.:

Synonyms:(3-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester

Suppliers and Price of (3-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester

There total 14 articles about (3-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 927187-47-1
(3-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NEt₃ / CH₂Cl₂ / 1 h / 0 °C

2.1: Pd(PPh₃)4 / dimethylformamide / 30 h / 80 °C

3.1: formic acid / Raney-nickel / 10 h / 110 °C

4.1: H₂NOH*HCl; aq. Na₂CO₃ / 2 h / 20 °C

5.1: NCS; HCl(gas) / dimethylformamide / 0.5 h / 20 °C

6.1: potassium bis(trimethylsilyl)amide / diethyl ether / 1 h / 20 °C

6.2: acetonitrile / 3 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; hydroxylamine hydrochloride; potassium hexamethylsilazane; sodium carbonate; triethylamine; nickel; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.08.052

Reference yield:

: 870194-71-1
N-[2-(2,4-dichlorophenoxy)ethyl]-3-oxo-3-phenylpropionamide

: C₁₀H₁₀ClNO₃

: 927187-47-1
(3-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester

Guidance literature:: N-[2-(2,4-dichlorophenoxy)ethyl]-3-oxo-3-phenylpropionamide; With potassium hexamethylsilazane; In diethyl ether; at 20 ℃; for 1h;

C₁₀H₁₀ClNO₃; In acetonitrile; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2006.08.052

Reference yield:

: 52798-00-2
(3-cyano-phenyl)-acetic acid methyl ester

: 927187-47-1
(3-{4-[2-(2,4-dichloro-phenoxy)-ethyl-carbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: formic acid / Raney-nickel / 10 h / 110 °C

2.1: H₂NOH*HCl; aq. Na₂CO₃ / 2 h / 20 °C

3.1: NCS; HCl(gas) / dimethylformamide / 0.5 h / 20 °C

4.1: potassium bis(trimethylsilyl)amide / diethyl ether / 1 h / 20 °C

4.2: acetonitrile / 3 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; formic acid; hydroxylamine hydrochloride; potassium hexamethylsilazane; sodium carbonate; nickel; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.08.052