52798-00-2

Basic information

• Product Name: METHYL (3-CYANOPHENYL)ACETATE
• Synonyms: METHYL (3-CYANOPHENYL)ACETATE;Benzeneacetic acid,3-cyano-, Methyl ester;3-Cyanobenzeneacetic acid methyl ester
• CAS NO: 52798-00-2
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Product Categories: pharmacetical
• Mol File: 52798-00-2.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 279.8 °C at 760 mmHg
• Flash Point: 127.1 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 0.00394mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: METHYL (3-CYANOPHENYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (3-CYANOPHENYL)ACETATE(52798-00-2)
• EPA Substance Registry System: METHYL (3-CYANOPHENYL)ACETATE(52798-00-2)

Safety Data

• Hazardous Substances Data: 52798-00-2(Hazardous Substances Data)

Usage

General Description

Methyl (3-cyanophenyl)acetate is a chemical compound with the molecular formula C10H9NO2. It is a colorless liquid with a fruity odor, commonly used as a flavoring agent in the food and beverage industry. It is also used in the production of fragrances and perfumes. Methyl (3-cyanophenyl)acetate can be synthesized through the esterification of 3-cyanophenol with methyl acetate in the presence of an acid catalyst. It is important to handle this chemical with care as it can be harmful if ingested, inhaled, or absorbed through the skin.

InChI:InChI=1/C10H9NO2/c1-13-10(12)6-8-3-2-4-9(5-8)7-11/h2-5H,6H2,1H3

Upstream product

• 557-21-1 dicyanozinc 
• 147283-87-2 methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate 
• 67-56-1 methanol 
• 1878-71-3 2-(3-cyanophenyl)acetic acid 
• 557-21-1 zinc(II) cyanide 
• 150529-73-0 methyl 2-(3-bromophenyl)acetatee 
• 1878-69-9 3-iodophenylacetic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 108-36-1 1,3-dibromobenzene 
• 1878-67-7 3-Bromophenylacetic acid 
• 42058-59-3 3-hydroxy-benzeneacetic acid, methyl ester 
• 621-37-4 m-hydroxyphenylacetic acid 
• 74-88-4 methyl iodide 
• 124-41-4 sodium methylate 

Downstream Products

• 2084-13-1 3-carboxymethyl-benzoic acid 
• 52787-20-9 3-methoxycarbonylphenylacetic acid methyl ester 
• 52787-19-6 2-(3-(methoxycarbonyl)phenyl) acetic acid 
• 1429653-88-2 methyl 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)benzoate 
• 1446499-66-6 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide 
• 1429652-59-4 N-hydroxy-3-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl) benzamide 
• 193290-27-6 3-(2-hydroxyethyl)benzonitrile 
• 223490-73-1 (3-(((2-(3-chloro-phenoxy)-ethyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenyl)-acetic acid methyl ester 
• 1249463-71-5 methyl 2-(3-cyanophenyl)propanoate 
• 1428789-43-8 2-(3-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428790-16-2 2-(3-(aminomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428790-15-1 2-(3-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428789-42-7 N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-(methylsulfonamidomethyl)phenyl)propanamide 
• 1428790-14-0 2-(3-(aminomethyl)phenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 

Relevant articles and documents

Pyridineacetamide derivative serving as CDK inhibitor, and preparation method and application thereof

The invention belongs to the technical field of pyridineacetamide derivatives, and particularly relates to a pyridineacetamide derivative serving as a CDK inhibitor and a preparation method and application of the pyridine acetamide derivative. The pyridineacetamide derivative shows excellent CDK9/CDK7 enzyme inhibitory activity, and can be used for preparing drugs used for treating cancers, especially hematologic cancers including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like and solid tumors such as breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.

Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety

A series of CAPE derivatives with mono-substituted phenylethanols moiety were synthesized and evaluated by MTT assay on growth of 4 human cancer cell lines (Hela, DU-145, MCF-7 and ECA-109). The substituent effects on the antiproliferative activity were systematically investigated for the first time. It was found that electron-donating and hydrophobic substituents at 2′-position of phenylethanol moiety could significantly enhance CAPE's antiproliferative activity. 2′-Propoxyl derivative, as a novel caffeic acid ester, exhibited exquisite potency (IC50?=?0.4?±?0.02 & 0.6?±?0.03?μM against Hela and DU-145 respectively).

COMPOUNDS AND THEIR METHODS OF USE

Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.