52798-00-2

Usage

Uses

Used in Food and Beverage Industry:
METHYL (3-CYANOPHENYL)ACETATE is used as a flavoring agent for its distinctive fruity aroma, enhancing the taste and appeal of various food and drink products.
Used in Fragrance and Perfume Industry:
METHYL (3-CYANOPHENYL)ACETATE is used as a component in fragrances and perfumes, contributing to the creation of complex and pleasant scents for personal care and cosmetic products.

InChI:InChI=1/C10H9NO2/c1-13-10(12)6-8-3-2-4-9(5-8)7-11/h2-5H,6H2,1H3

Upstream product

• 544-92-3 copper(I) cyanide 
• 150529-73-0 methyl 2-(3-bromophenyl)acetatee 
• 124-41-4 sodium methylate 
• 203805-69-0 8-Oxo-bicyclo[4.2.0]octa-1⁽⁶⁾,2,4-triene-2-carbonitrile 
• 67-56-1 methanol 
• 1878-71-3 2-(3-cyanophenyl)acetic acid 
• 557-21-1 zinc(II) cyanide 
• 1878-69-9 3-iodophenylacetic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 203805-66-7 8-Oxo-bicyclo[4.2.0]octa-1⁽⁶⁾,2,4-triene-2-carboxylic acid 
• 108-36-1 1,3-dibromobenzene 
• 1878-67-7 3-Bromophenylacetic acid 
• 42058-59-3 3-hydroxy-benzeneacetic acid, methyl ester 
• 621-37-4 m-hydroxyphenylacetic acid 

Downstream Products

• 142327-44-4 methyl 3-formylphenylacetate 
• 577776-93-3 methyl 2-(3-cyanophenyl)-3-oxobutanoate 
• 2084-13-1 3-carboxymethyl-benzoic acid 
• 52787-20-9 3-methoxycarbonylphenylacetic acid methyl ester 
• 52787-19-6 2-(3-(methoxycarbonyl)phenyl) acetic acid 
• 1429653-88-2 methyl 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)benzoate 
• 1446499-66-6 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide 
• 1429652-59-4 N-hydroxy-3-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl) benzamide 
• 223490-73-1 (3-(((2-(3-chloro-phenoxy)-ethyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenyl)-acetic acid methyl ester 
• 193290-27-6 3-(2-hydroxyethyl)benzonitrile 
• 1249463-71-5 methyl 2-(3-cyanophenyl)propanoate 
• 1428789-43-8 2-(3-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428790-16-2 2-(3-(aminomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428790-15-1 2-(3-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 

Relevant academic research and scientific papers

Pyridineacetamide derivative serving as CDK inhibitor, and preparation method and application thereof

The invention belongs to the technical field of pyridineacetamide derivatives, and particularly relates to a pyridineacetamide derivative serving as a CDK inhibitor and a preparation method and application of the pyridine acetamide derivative. The pyridineacetamide derivative shows excellent CDK9/CDK7 enzyme inhibitory activity, and can be used for preparing drugs used for treating cancers, especially hematologic cancers including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like and solid tumors such as breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.

Photoinduced Copper(I)-Catalyzed Cyanation of Aromatic Halides at Room Temperature

The first photoinduced copper(I)-catalyzed cyanation of aromatic halides at room temperature has been developed. The sp2 cyanation reaction exhibits outstanding tolerance to functional groups including primary amines and carboxylic acids, and chemoselectivity to SN2-reactive alkyl chlorides. Mechanistic investigations indicate that the reaction occurs via a single-electron transfer (SET) between the aryl halide and an excited copper(I) cyanide catalytic intermediate. (Figure presented.).

Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety

A series of CAPE derivatives with mono-substituted phenylethanols moiety were synthesized and evaluated by MTT assay on growth of 4 human cancer cell lines (Hela, DU-145, MCF-7 and ECA-109). The substituent effects on the antiproliferative activity were systematically investigated for the first time. It was found that electron-donating and hydrophobic substituents at 2′-position of phenylethanol moiety could significantly enhance CAPE's antiproliferative activity. 2′-Propoxyl derivative, as a novel caffeic acid ester, exhibited exquisite potency (IC50?=?0.4?±?0.02 & 0.6?±?0.03?μM against Hela and DU-145 respectively).

Preparation method of 2-(3-cyanobenzyl)pyrrolidine

The invention discloses a preparation method of 2-(3-cyanobenzyl)pyrrolidine. The desired product is prepared from p-bromophenylacetic acid as a starting material through esterification, coupling, ring opening, ring closure and reduction. The compound is an important pharmaceutical intermediate.

COMPOUNDS AND THEIR METHODS OF USE

Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES AS GLUTAMINASE INHIBITORS FOR TREATING CANCERS THEREOF

Provided are compounds of formula (I), wherein X, Y, Z, W, m, n, o, p, R1, R2 and R6 are defined as in the description. Pharmaceutical compositions and uses as glutaminase inhibitors for treating cancers thereof are also provided.

COMPOUNDS AND THEIR METHODS OF USE

Provided are compounds of formula (I), which can inhibit glutaminase. Pharmaceutical compositions comprising these compounds and uses as glutaminase inhibitors for treating cancers thereof are also provided.

NOVEL MOLECULES THAT SELECTIVELY INHIBIT HISTONE DEACETYLASE 6 RELATIVE TO HISTONE DEACETYLASE 1

The compounds of the present invention are HDAC6 selective inhibitors which are identified on the basis of accumulation of acetylated tubulin without accumulation of acetylated histones. Histone deacetylase or "HDAC" refers to enzymes capable of cleaving an acetyl group (-C(=0)CH3) from proteins, including histone and microtubulins. Compositions comprising the molecules and methods for their use to inhibit the activity of histone deacetylase, including for treatment, are also disclosed.

Aryl or N-heteroaryl Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands

The invention relates to aryl or N-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

ARYL OR N-HETEROARYL SUBSTITUTED METHANESULFONAMIDE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to aryl or N-heteroaryl substituted methanesulfonamide derivatives of Formula (I) as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.