4-cyclopropylaminothieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide

Base Information

Chemical Name:4-cyclopropylaminothieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide
CAS No.:1269666-83-2
Molecular Formula:C₁₉H₁₉Cl₂N₅O₃S₂
Molecular Weight:500.43
Hs Code.:

Synonyms:4-cyclopropylaminothieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide

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Chemical Property of 4-cyclopropylaminothieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-cyclopropylaminothieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide

There total 11 articles about 4-cyclopropylaminothieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1269667-60-8
4-chloro-N-(2,6-dichloro-3-(propylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide

: 765-30-0
Cyclopropylamine

: 1269666-83-2
4-cyclopropylaminothieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 60 ℃; for 1h;

Reference yield:

: 16234-10-9
3H-thieno[3,2-d]pyrimidin-4-one

: 1269666-83-2
4-cyclopropylaminothieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine / acetic acid / 8 h / 100 °C

1.2: 20 °C

2.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 3 h / 120 °C / 15514.9 Torr / Autoclave

3.1: trichlorophosphate / 2 h / Reflux

3.2: Cooling with ice

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 20 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 0 - 20 °C

6.1: pyridine / chloroform / 2 h / 55 °C

7.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 1 h / 60 °C

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; water; bromine; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran; chloroform; acetic acid; isopropyl alcohol;

Reference yield:

: 31169-25-2
7-bromothieno[3,2-d]pyrimidine-4(3H)-one

: 1269666-83-2
4-cyclopropylaminothieno[3,2-d]pyrimidine-7-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)phenyl]amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 3 h / 120 °C / 15514.9 Torr / Autoclave

2.1: trichlorophosphate / 2 h / Reflux

2.2: Cooling with ice

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 0 - 20 °C

5.1: pyridine / chloroform / 2 h / 55 °C

6.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 1 h / 60 °C

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; water; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran; chloroform; isopropyl alcohol;