Chromanol 293B

Base Information

Chemical Name:Chromanol 293B
CAS No.:163163-23-3
Molecular Formula:C₁₅H₂₀N₂O₄S
Molecular Weight:324.401
Hs Code.:
European Community (EC) Number:634-078-8
DSSTox Substance ID:DTXSID00167526
Nikkaji Number:J758.770H
Wikidata:Q27073735
Metabolomics Workbench ID:68136
ChEMBL ID:CHEMBL434045
Mol file:163163-23-3.mol

Synonyms:293B cpd;6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane;6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane, (trans-(+))-isomer;6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane, (trans-(-))-isomer;chromanol 293B

Suppliers and Price of Chromanol 293B

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Chromanol 293B
10mg
$ 466.00

TRC
Chromanol 293B
1mg
$ 60.00

Tocris
Chromanol 293B ≥99%(HPLC)
50
$ 752.00

Tocris
Chromanol 293B ≥99%(HPLC)
10
$ 179.00

Sigma-Aldrich
Chromanol 293B ≥98% (HPLC), powder
10mg
$ 173.00

Sigma-Aldrich
Chromanol 293B ≥98% (HPLC), powder
50mg
$ 758.00

Cayman Chemical
Chromanol 293B ≥98%
50mg
$ 500.00

Cayman Chemical
Chromanol 293B ≥98%
10mg
$ 138.00

Cayman Chemical
Chromanol 293B ≥98%
1mg
$ 25.00

Cayman Chemical
Chromanol 293B ≥98%
5mg
$ 94.00

Total 7 raw suppliers

Chemical Property of Chromanol 293B

Chemical Property:

Vapor Pressure:8.52E-10mmHg at 25°C
Boiling Point:474.1°Cat760mmHg
PKA:12.96±0.60(Predicted)
Flash Point:240.6°C
PSA：99.01000
Density:1.33g/cm³
LogP:2.49358
Storage Temp.:−20°C
Solubility.:DMSO: 18 mg/mL
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:324.11437830
Heavy Atom Count:22
Complexity:560

Purity/Quality:

98%,99%, ^*data from raw suppliers

Chromanol 293B ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 20/21/22
Safety Statements: 36/37-7/9

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCS(=O)(=O)N(C)C1C(C(OC2=C1C=C(C=C2)C#N)(C)C)O
Isomeric SMILES:CCS(=O)(=O)N(C)[C@@H]1[C@H](C(OC2=C1C=C(C=C2)C#N)(C)C)O
Description Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) with an IC50 value of 6.89 μM in Xenopus oocytes expressing rat IKs channels. It is selective, having no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 μM. Chromanol 293B increases the rate and extent of IKs in guinea pig ventricular cells in a dose-dependent manner. It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl- currents (ICTFR) with an IC50 value of 19 μM in Xenopus oocytes expressing human CTFR.
Uses Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.

Technology Process of Chromanol 293B

There total 13 articles about Chromanol 293B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: N-((3R,4S)-6-cyano-3-methoxy-2,2-dimethylchroman-4-yl)-N-methylethanesulfonamide

: 163163-23-3,163163-24-4
(-)-Chromanol 293B

Guidance literature:: With boron tribromide; In dichloromethane; at -78 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.tetlet.2019.151431

Reference yield:

: 6601-37-2
N-methyl-ethanesulfonamide

: 65018-90-8
3,4-epoxy-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile

: 163163-23-3
chromanol 293B

Guidance literature:: N-methyl-ethanesulfonamide; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.333333h;

3,4-epoxy-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile; In dimethyl sulfoxide; at 20 - 45 ℃; Further stages.;
DOI:10.1021/jm0109255

Reference yield:

: 6601-37-2
N-methyl-ethanesulfonamide

: 65018-90-8,75611-72-2,114926-02-2,114926-03-3
(1aR-cis)-1a,7b-dihydro-2,2-dimethyl-2H-oxireno[c][1]benzopyran-6-carbonitrile

: 163163-23-3,163163-24-4
(-)-Chromanol 293B

Guidance literature:: N-methyl-ethanesulfonamide; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.333333h;

(1aR-cis)-1a,7b-dihydro-2,2-dimethyl-2H-oxireno[c][1]benzopyran-6-carbonitrile; In dimethyl sulfoxide; at 20 - 45 ℃; Further stages.;
DOI:10.1021/jm0109255