2-(3,4-Dimethoxy-phenyl)-N-(2-pyrrol-1-yl-benzyl)-acetamide

Base Information

• Chemical Name: 2-(3,4-Dimethoxy-phenyl)-N-(2-pyrrol-1-yl-benzyl)-acetamide
• CAS No.: 171413-43-7
• Molecular Formula: C₂₁H₂₂N₂O₃
• Molecular Weight: 350.417
• Mol file: 171413-43-7.mol

Synonyms:2-(3,4-Dimethoxy-phenyl)-N-(2-pyrrol-1-yl-benzyl)-acetamide

Chemical Property of 2-(3,4-Dimethoxy-phenyl)-N-(2-pyrrol-1-yl-benzyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-(3,4-Dimethoxy-phenyl)-N-(2-pyrrol-1-yl-benzyl)-acetamide

There total 1 articles about 2-(3,4-Dimethoxy-phenyl)-N-(2-pyrrol-1-yl-benzyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) + 2-(1-pyrrolyl)benzylamine (39243-88-4) → 2-(3,4-Dimethoxy-phenyl)-N-(2-pyrrol-1-yl-benzyl)-acetamide (171413-43-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; for 2h; Ambient temperature;

DOI:10.1016/0223-5234(96)88274-2

Reference yield: 76.1%

2-(3,4-Dimethoxy-phenyl)-N-(2-pyrrol-1-yl-benzyl)-acetamide (171413-43-7) → [2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-pyrrol-1-yl-benzyl)-amine

Guidance literature:

With sodium tetrahydroborate; acetic acid; In 1,4-dioxane; at 100 ℃; for 14h;

DOI:10.1016/0223-5234(96)88274-2

Reference yield:

2-(3,4-Dimethoxy-phenyl)-N-(2-pyrrol-1-yl-benzyl)-acetamide (171413-43-7) → 4-(3,4-Dimethoxy-benzyl)-5-methyl-5,6-dihydro-4H-benzo[f]pyrrolo[1,2-a][1,4]diazepine

Guidance literature:

Multi-step reaction with 3 steps

1: phosphoryl chloride / 2 h / 40 °C

2: sodium borohydride / aq. ethanol / 48 h / Ambient temperature

3: 87.7 percent / H₂ / 10percent Pd/C / aq. ethanol / 4 h / Ambient temperature

With sodium tetrahydroborate; hydrogen; trichlorophosphate; palladium on activated charcoal; In ethanol;

DOI:10.1016/0223-5234(96)88274-2

upstream raw materials:

(3,4-Dimethoxyphenyl)acetic acid

2-(1-pyrrolyl)benzylamine

Downstream raw materials:

4-(3,4-Dimethoxy-benzyl)-6H-benzo[f]pyrrolo[1,2-a][1,4]diazepine

4-(3,4-Dimethoxy-benzyl)-5,6-dihydro-4H-benzo[f]pyrrolo[1,2-a][1,4]diazepine