(Z)-4-(3-(2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetoxy)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

Base Information

Chemical Name:(Z)-4-(3-(2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetoxy)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide
CAS No.:1538580-63-0
Molecular Formula:C₃₄H₂₅FN₂O₇S₂
Molecular Weight:656.712
Hs Code.:

Synonyms:(Z)-4-(3-(2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetoxy)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

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Chemical Property of (Z)-4-(3-(2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetoxy)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

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Technology Process of (Z)-4-(3-(2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetoxy)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

There total 4 articles about (Z)-4-(3-(2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetoxy)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1015251-31-6
4-(3-hydroxyphenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

: 49627-27-2
sulindac sulfide

: 1538580-63-0
(Z)-4-(3-(2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetoxy)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.12.014

Reference yield:

: 38194-50-2
Sulindac

: 1538580-63-0
(Z)-4-(3-(2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetoxy)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: titanium tetrachloride; zinc / dichloromethane; tetrahydrofuran / 2.5 h / Cooling with acetone-dry ice; Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 20 °C / Inert atmosphere

With dmap; titanium tetrachloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2013.12.014

Reference yield:

: 108-46-3
recorcinol

: 1538580-63-0
(Z)-4-(3-(2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetoxy)phenoxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran / 3 h / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2013.12.014