1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole

Base Information

• Chemical Name: 1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole
• CAS No.: 1187480-59-6
• Molecular Formula: C₂₃H₂₄FN₇O₂
• Molecular Weight: 449.488

Synonyms:1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole

Chemical Property of 1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole

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Technology Process of 1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole

There total 1 articles about 1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-tert-butoxycarbonyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole (1071930-80-7) → 1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole (1187480-59-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; water; at 20 ℃; for 2.5h;

DOI:10.1021/jm800800c

Reference yield:

1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole (1187480-59-6) → 1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole dihydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; water; at 0 ℃;

DOI:10.1021/jm800800c

upstream raw materials:

1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-tert-butoxycarbonyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole

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