1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-tert-butoxycarbonyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole

Base Information

• Chemical Name: 1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-tert-butoxycarbonyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole
• CAS No.: 1071930-80-7
• Molecular Formula: C₂₈H₃₂FN₇O₄
• Molecular Weight: 549.605

Synonyms:1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-tert-butoxycarbonyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole

Chemical Property of 1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-tert-butoxycarbonyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole

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Technology Process of 1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-tert-butoxycarbonyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole

There total 1 articles about 1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-tert-butoxycarbonyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1-[5(R)-3-[4-[2-[(1α,5α,6β)-3-tert-butoxycarbonyl-6-cyano-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole → 1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-tert-butoxycarbonyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole (1071930-80-7)

Guidance literature:

With sodium tetrahydroborate; cobalt(II) chloride hexahydrate; In methanol; at 20 ℃; for 24h;

DOI:10.1021/jm800800c

Reference yield:

1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-tert-butoxycarbonyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole (1071930-80-7) → 1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole (1187480-59-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; water; at 20 ℃; for 2.5h;

DOI:10.1021/jm800800c

Downstream raw materials:

1-[5(R)-3-[4-[4-[(1α,5α,6β)-6-aminomethyl-3-azabicyclo[3.1.0]hexan-6-yl]pyridin-5-yl]-3-fluorophenyl]-2-oxooxazolidin-5-ylmethyl]-1,2,3-triazole

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