(2S)-2-[1-hydroxy-2-(1,3-dioxoisoindole)hexyl]-5-chloro-6-methoxylnaphthaline

Base Information

Chemical Name:(2S)-2-[1-hydroxy-2-(1,3-dioxoisoindole)hexyl]-5-chloro-6-methoxylnaphthaline
CAS No.:1221409-50-2
Molecular Formula:C₂₅H₂₄ClNO₄
Molecular Weight:437.923
Hs Code.:

Synonyms:(2S)-2-[1-hydroxy-2-(1,3-dioxoisoindole)hexyl]-5-chloro-6-methoxylnaphthaline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-[1-hydroxy-2-(1,3-dioxoisoindole)hexyl]-5-chloro-6-methoxylnaphthaline

Chemical Property:

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Technology Process of (2S)-2-[1-hydroxy-2-(1,3-dioxoisoindole)hexyl]-5-chloro-6-methoxylnaphthaline

There total 1 articles about (2S)-2-[1-hydroxy-2-(1,3-dioxoisoindole)hexyl]-5-chloro-6-methoxylnaphthaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85-44-9
phthalic anhydride

: 1221409-50-2
(2S)-2-[1-hydroxy-2-(1,3-dioxoisoindole)hexyl]-5-chloro-6-methoxylnaphthaline

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / toluene / 24 h / 110 °C / Reflux

2.1: oxalyl dichloride / pyridine / dichloromethane / 20 h / 0 - 20 °C

3.1: aluminum (III) chloride / dichloromethane / 30 h / 20 °C

3.2: Cooling with ice

4.1: aluminum isopropoxide / isopropyl alcohol; toluene / 4 h / 100 °C

With aluminum (III) chloride; oxalyl dichloride; aluminum isopropoxide; triethylamine; pyridine; In dichloromethane; isopropyl alcohol; toluene; 3.1: Friedel Crafts Acylation;

Reference yield:

: 1221409-50-2
(2S)-2-[1-hydroxy-2-(1,3-dioxoisoindole)hexyl]-5-chloro-6-methoxylnaphthaline

: 1221409-16-0
(1R,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / 3 h / 20 °C

2: triethylamine / acetonitrile / 20 h / Reflux

3: dichloromethane; methanol / Resolution of racemate

With hydrazine hydrate; triethylamine; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 1221409-50-2
(2S)-2-[1-hydroxy-2-(1,3-dioxoisoindole)hexyl]-5-chloro-6-methoxylnaphthaline

: 1221409-17-1
(1S,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / 3 h / 20 °C

2: triethylamine / acetonitrile / 20 h / Reflux

3: dichloromethane; methanol / Resolution of racemate

With hydrazine hydrate; triethylamine; In methanol; dichloromethane; acetonitrile;