(1R,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

Base Information

Chemical Name:(1R,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol
CAS No.:1221409-16-0
Molecular Formula:C₂₈H₃₅ClN₂O₂
Molecular Weight:467.051
Hs Code.:

Synonyms:(1R,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

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Chemical Property of (1R,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

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Technology Process of (1R,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

There total 21 articles about (1R,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 55-51-6
N,N-bis(2-chloro-ethyl)-benzenemethanamine

: 1411976-02-7
(1R,2S)-2-amino-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

: 1221409-16-0
(1R,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 8h; Reflux;
DOI:10.1021/op300258w

Reference yield:

: 1221409-15-9
(1S)-N₁-benzyl-N₄-[1-butyl-2-hydroxy-2-(5'-chloro-6'-methoxyl-2'-naphthyl)ethyl]piperazine

: 1221409-17-1
(1S,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

: 1221409-16-0
(1R,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

Guidance literature:: In methanol; dichloromethane; Resolution of racemate;

Reference yield:

: 1411976-00-5
(2S)-1-(5-chloro-6-methoxynaphthalen-2-yl)-2-(((S)-1-phenylethyl)amino)hexan-1-one

: 1221409-16-0
(1R,2S)-2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 1 h / 10 - 25 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 60 °C / 3750.38 Torr

3: triethylamine / acetonitrile / 8 h / 20 °C / Reflux

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; acetonitrile;
DOI:10.1021/op300258w