(2S,5S)-tert-butyl 2-methyl-5-(tosyloxymethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,5S)-tert-butyl 2-methyl-5-(tosyloxymethyl)pyrrolidine-1-carboxylate
CAS No.:1334123-94-2
Molecular Formula:C₁₈H₂₇NO₅S
Molecular Weight:369.482
Hs Code.:

Synonyms:(2S,5S)-tert-butyl 2-methyl-5-(tosyloxymethyl)pyrrolidine-1-carboxylate

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Chemical Property of (2S,5S)-tert-butyl 2-methyl-5-(tosyloxymethyl)pyrrolidine-1-carboxylate

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Technology Process of (2S,5S)-tert-butyl 2-methyl-5-(tosyloxymethyl)pyrrolidine-1-carboxylate

There total 5 articles about (2S,5S)-tert-butyl 2-methyl-5-(tosyloxymethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 104-15-4
toluene-4-sulfonic acid

: 441716-79-6
(2S,5S)-tert-butyl 2-(hydroxymethyl)-5-methylpyrrolidine-1-carboxylate

: 1334123-94-2
(2S,5S)-tert-butyl 2-methyl-5-(tosyloxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: With triethylamine; dmap; In chloroform; at 0 - 20 ℃; for 6h;

Reference yield:

: 676560-84-2,166941-67-9
(2S,5S)-5-methylpyrrolidine-2-carboxylic acid ethyl ester

: 1334123-94-2
(2S,5S)-tert-butyl 2-methyl-5-(tosyloxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / chloroform / 24 h / 20 °C

2: sodium tetrahydroborate; calcium chloride / ethanol / 20 °C

3: triethylamine / dmap / chloroform / 6 h / 0 - 20 °C

With sodium tetrahydroborate; triethylamine; calcium chloride; dmap; In ethanol; chloroform;

Reference yield:

: 913251-58-8
(S)-2-(tert-butoxycarbonylamino)-5-oxohexanoic acid ethyl ester

: 1334123-94-2
(2S,5S)-tert-butyl 2-methyl-5-(tosyloxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 60 °C

2: hydrogen / palladium on activated charcoal / ethanol / 48 h

3: triethylamine / chloroform / 24 h / 20 °C

4: sodium tetrahydroborate; calcium chloride / ethanol / 20 °C

5: triethylamine / dmap / chloroform / 6 h / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; hydrogen; triethylamine; calcium chloride; dmap; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform;