{(2R,4R)-4-Benzyloxy-4-[(4R,5S,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-2-methyl-pentyloxy}-tert-butyl-dimethyl-silane

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Chemical Name:{(2R,4R)-4-Benzyloxy-4-[(4R,5S,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-2-methyl-pentyloxy}-tert-butyl-dimethyl-silane
CAS No.:114114-21-5
Molecular Formula:C₃₅H₅₄O₅Si
Molecular Weight:582.896
Hs Code.:

Synonyms:{(2R,4R)-4-Benzyloxy-4-[(4R,5S,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-2-methyl-pentyloxy}-tert-butyl-dimethyl-silane

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Chemical Property of {(2R,4R)-4-Benzyloxy-4-[(4R,5S,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-2-methyl-pentyloxy}-tert-butyl-dimethyl-silane

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Technology Process of {(2R,4R)-4-Benzyloxy-4-[(4R,5S,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-2-methyl-pentyloxy}-tert-butyl-dimethyl-silane

There total 26 articles about {(2R,4R)-4-Benzyloxy-4-[(4R,5S,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-2-methyl-pentyloxy}-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 114137-89-2
(3S,4R,5S,6R,7R,9R)-7-Benzyloxy-10-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-3,5,7,9-tetramethyl-dec-1-en-4-ol

: 114114-21-5
{(2R,4R)-4-Benzyloxy-4-[(2R,4R,5S,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-2-methyl-pentyloxy}-tert-butyl-dimethyl-silane

Guidance literature:: With MS 3 Angstroem; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;
DOI:10.1016/S0040-4039(00)96400-1

Reference yield: 81.0%

: 114137-89-2
(3S,4R,5S,6R,7R,9R)-7-Benzyloxy-10-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-3,5,7,9-tetramethyl-dec-1-en-4-ol

: 114114-21-5
{(2R,4R)-4-Benzyloxy-4-[(4R,5S,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-2-methyl-pentyloxy}-tert-butyl-dimethyl-silane

Guidance literature:: With 3 A molecular sieve; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; for 0.5h;
DOI:10.1007/BF00958058

Reference yield:

: 114114-18-0
(2R,4R)-2-benzyloxy-5-tert-butyldimethylsiloxy-2,4-dimethylpentanal

: 114114-21-5
{(2R,4R)-4-Benzyloxy-4-[(4R,5S,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-2-methyl-pentyloxy}-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 64 percent / MgBr₂ / CH₂Cl₂ / 50 h / 25 °C

2: 1) NaH / 1) DMF, 25 deg C, 1 h, 2) overnight

3: 1) NMO-monohydrate, OsO₄, 2) K₂S₂O₅ / 1) acetone, H₂O, 25 deg C, 12 h, 2) 1 h

4: NaIO₄ / tetrahydrofuran; H₂O

5: 72 percent / BF₃*Et₂O / CH₂Cl₂ / 0.75 h / -78 °C

6: 81 percent / DDQ, 3 Angstroem molecular sieves / CH₂Cl₂ / 0.5 h / 25 °C

With potassium disulphite; sodium periodate; osmium(VIII) oxide; 3 A molecular sieve; boron trifluoride diethyl etherate; sodium hydride; 4-methylmorpholine N-oxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; magnesium bromide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4020(01)96139-3