(S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(1-methyl-2-trimethylsilanyl-ethyl) ester

Base Information

• Chemical Name: (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(1-methyl-2-trimethylsilanyl-ethyl) ester
• CAS No.: 702702-43-0
• Molecular Formula: C₁₉H₂₉NO₄Si
• Molecular Weight: 363.529
• Mol file: 702702-43-0.mol

Synonyms:(S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(1-methyl-2-trimethylsilanyl-ethyl) ester

Chemical Property of (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(1-methyl-2-trimethylsilanyl-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(1-methyl-2-trimethylsilanyl-ethyl) ester

There total 1 articles about (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(1-methyl-2-trimethylsilanyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethylsilyl-2-hydroxypropane (121386-65-0,145428-84-8,145428-85-9) + N-Benzyloxycarbonyl-L-proline (1148-11-4) → (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(1-methyl-2-trimethylsilanyl-ethyl) ester (702702-43-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/j.tetlet.2004.03.054

Reference yield:

N-carbobenzyloxy-L-tryptophane (7432-21-5) + (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(1-methyl-2-trimethylsilanyl-ethyl) ester (702702-43-0) → Z-Trp-Pro-OTmsi (702702-46-3)

Guidance literature:

(S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(1-methyl-2-trimethylsilanyl-ethyl) ester; With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In water; ethyl acetate; at 20 ℃; under 750.075 Torr;

N-carbobenzyloxy-L-tryptophane; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; ethyl acetate; Further stages.;

DOI:10.1016/j.tetlet.2004.03.054

upstream raw materials:

trimethylsilyl-2-hydroxypropane

N-Benzyloxycarbonyl-L-proline

Downstream raw materials:

Z-Trp-Pro-OTmsi