Technology Process of Z-Trp-Pro-OTmsi
There total 3 articles about Z-Trp-Pro-OTmsi which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(1-methyl-2-trimethylsilanyl-ethyl) ester;
With
4-methyl-morpholine; hydrogen;
palladium on activated charcoal;
In
water; ethyl acetate;
at 20 ℃;
under 750.075 Torr;
N-carbobenzyloxy-L-tryptophane;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
water; ethyl acetate;
Further stages.;
DOI:10.1016/j.tetlet.2004.03.054
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: DCC; DMAP / CH2Cl2
2.1: H2; N-methylmorpholine / Pd/C / ethyl acetate; H2O / 20 °C / 750.08 Torr
2.2: 1-(3'-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt / ethyl acetate; H2O
With
4-methyl-morpholine; dmap; hydrogen; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
dichloromethane; water; ethyl acetate;
DOI:10.1016/j.tetlet.2004.03.054
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: DCC; DMAP / CH2Cl2
2.1: H2; N-methylmorpholine / Pd/C / ethyl acetate; H2O / 20 °C / 750.08 Torr
2.2: 1-(3'-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt / ethyl acetate; H2O
With
4-methyl-morpholine; dmap; hydrogen; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
dichloromethane; water; ethyl acetate;
DOI:10.1016/j.tetlet.2004.03.054
