(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Base Information

Chemical Name:(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
CAS No.:1228215-10-8
Molecular Formula:C₁₂H₁₉NO₄
Molecular Weight:241.287
Hs Code.:

Synonyms:(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

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Chemical Property of (S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

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Technology Process of (S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

There total 1 articles about (S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1228215-10-8
(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

2: pyridinium chlorochromate / dichloromethane / 20 °C

3: sodium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

4: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 5 h / Reflux

With potassium fluoride; sodium hexamethyldisilazane; triethylamine; pyridinium chlorochromate; sodium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1228215-10-8
(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: (S)-tert-butyl 2-(5-(4-((2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-benzo[d]imidazol-6-yl)ethynyl)phenyl)-1H-imidazol-2-yl)-4-methyl-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

1.2: pH 3

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

3.1: triethylamine; ammonium acetate / xylene / 2 h / 140 °C / sealed tube

4.1: N-ethyl-N,N-diisopropylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / Inert atmosphere; Reflux

5.1: potassium carbonate; methanol / tetrahydrofuran / 3 h / 20 °C

6.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 110 °C / sealed tube

With methanol; lithium hydroxide monohydrate; ammonium acetate; water; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; xylene; 4.1: Sonogashira Coupling / 6.1: Sonogashira Coupling;

Reference yield:

: 1228215-10-8
(S)-4-methyl-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1352392-97-2
6-((4-(2-((S)-4-methyl-2,5-dihydro-1H-pyrrol-2-yl)-1H-imidazol-5-yl)phenyl)ethynyl)-2-((S)-pyrrolidin-2-yl)-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 °C

1.2: pH 3

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

3.1: triethylamine; ammonium acetate / xylene / 2 h / 140 °C / sealed tube

4.1: N-ethyl-N,N-diisopropylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / Inert atmosphere; Reflux

5.1: potassium carbonate; methanol / tetrahydrofuran / 3 h / 20 °C

6.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 110 °C / sealed tube

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With methanol; lithium hydroxide monohydrate; ammonium acetate; water; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; xylene; 4.1: Sonogashira Coupling / 6.1: Sonogashira Coupling;