Technology Process of 3-{2-[(4-methoxybenzyl)oxy]ethyl}oxetan-3-ylethanal
There total 5 articles about 3-{2-[(4-methoxybenzyl)oxy]ethyl}oxetan-3-ylethanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C15H22O4;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
for 0.666667h;
Inert atmosphere;
With
triethylamine;
In
dichloromethane;
for 0.5h;
Inert atmosphere;
DOI:10.1016/j.tetlet.2014.05.060
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.33 h / 0 - 20 °C / Inert atmosphere
1.2: 18 h
2.1: sodium chloride / dimethyl sulfoxide; water / 3 h / 160 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 - 20 °C / Inert atmosphere
4.1: sodium hydride; tetra-(n-butyl)ammonium iodide / mineral oil; tetrahydrofuran / 24 h / -20 - 20 °C / Inert atmosphere
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.67 h / -78 °C / Inert atmosphere
5.2: 255 / 0.5 h / Inert atmosphere
With
lithium aluminium tetrahydride; oxalyl dichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; sodium chloride;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; mineral oil;
5.1: |Swern Oxidation / 5.2: |Swern Oxidation;
DOI:10.1016/j.tetlet.2014.05.060
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride; tetra-(n-butyl)ammonium iodide / mineral oil; tetrahydrofuran / 24 h / -20 - 20 °C / Inert atmosphere
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.67 h / -78 °C / Inert atmosphere
2.2: 255 / 0.5 h / Inert atmosphere
With
oxalyl dichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; mineral oil;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1016/j.tetlet.2014.05.060
