((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methyl methanesulfonate

Base Information

• Chemical Name: ((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methyl methanesulfonate
• CAS No.: 1610035-75-0
• Molecular Formula: C₂₆H₃₅ClFN₃O₆S
• Molecular Weight: 572.098
• Mol file: 1610035-75-0.mol

Synonyms:((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methyl methanesulfonate

Chemical Property of ((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methyl methanesulfonate

There total 10 articles about ((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol (1610035-74-9) + methanesulfonyl chloride (124-63-0) → ((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methyl methanesulfonate (1610035-75-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.666667h;

Reference yield:

5-chloro-4-((3,4-trans)-4-(2-fluoro-4-iodophenoxy)-3-methylpiperidin1-yl)-2-methoxypyridine → ((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methyl methanesulfonate (1610035-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; copper(l) iodide / butan-1-ol / 12 h / 92 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.67 h / 0 °C

With copper(l) iodide; triethylamine; sodium hydroxide; In dichloromethane; butan-1-ol;

Reference yield:

1-benzyl 2-methyl (R)-4-((tert-butyldimethylsilyl)oxy)-4.5-dihydro-1H-pyrrole-1,2-dicarboxylate (1367552-62-2) → ((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methyl methanesulfonate (1610035-75-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 1 h

1.2: 0.75 h / -45 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 20 °C

4.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

6.1: sodium hydroxide; copper(l) iodide / butan-1-ol / 12 h / 92 °C / Inert atmosphere

7.1: triethylamine / dichloromethane / 0.67 h / 0 °C

With copper(l) iodide; lithium borohydride; copper(I) bromide dimethylsulfide complex; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil; butan-1-ol;

upstream raw materials:

((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol

methanesulfonyl chloride

1-benzyl 2-methyl (R)-4-((tert-butyldimethylsilyl)oxy)-4.5-dihydro-1H-pyrrole-1,2-dicarboxylate

(2R,3S,4R)-1-benzyl 2-methyl 4-((tert-butyldimethylsilyl)oxy)-3-methylpyrrolidine-1,2-dicarboxylate

Downstream raw materials:

2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetic acid

2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile