Technology Process of (-)-(2R,4R)-N,N-dibenzyl-1,2:4,5-diepoxypentan-3-amine
There total 7 articles about (-)-(2R,4R)-N,N-dibenzyl-1,2:4,5-diepoxypentan-3-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methyllithium;
In
tetrahydrofuran; diethyl ether;
at -78 - 20 ℃;
DOI:10.1021/jo015920u
- Guidance literature:
-
Multi-step reaction with 4 steps
1: MeLi / tetrahydrofuran; diethyl ether / -78 - 20 °C
2: Bu4NF / tetrahydrofuran / 48 h / 20 °C
3: DMSO; oxalyl chloride / CH2Cl2 / 0.42 h / -63 °C
4: MeLi / tetrahydrofuran; diethyl ether / -78 - 20 °C
With
oxalyl dichloride; tetrabutyl ammonium fluoride; methyllithium; dimethyl sulfoxide;
In
tetrahydrofuran; diethyl ether; dichloromethane;
3: Swern oxidation;
DOI:10.1021/jo015920u
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / MeLi / tetrahydrofuran; diethyl ether / 0.5 h / -78 °C
2: LiAlH4 / tetrahydrofuran / 6 h / -100 °C
3: 87 percent / MeLi / tetrahydrofuran; diethyl ether / 1 h / 25 °C
4: Bu4NF / tetrahydrofuran / 48 h / 20 °C
5: DMSO; oxalyl chloride / CH2Cl2 / 0.42 h / -63 °C
6: MeLi / tetrahydrofuran; diethyl ether / -78 - 20 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; tetrabutyl ammonium fluoride; methyllithium; dimethyl sulfoxide;
In
tetrahydrofuran; diethyl ether; dichloromethane;
5: Swern oxidation;
DOI:10.1021/jo015920u
