Propanal, 2-[bis(phenylmethyl)amino]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)-

Base Information

Chemical Name:Propanal, 2-[bis(phenylmethyl)amino]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)-
CAS No.:125654-82-2
Molecular Formula:C23H33NO2Si
Molecular Weight:383.606
Hs Code.:
Mol file:125654-82-2.mol

Synonyms:

Suppliers and Price of Propanal, 2-[bis(phenylmethyl)amino]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Propanal, 2-[bis(phenylmethyl)amino]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Propanal, 2-[bis(phenylmethyl)amino]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)-

There total 4 articles about Propanal, 2-[bis(phenylmethyl)amino]-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 352530-50-8
methyl (S)-3-(tert-butyldimethylsilyloxy)-2-(dibenzylamino)propanoate

: 125654-82-2
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-dibenzylamino-propionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / LiBH₄ / methanol; diethyl ether / 0 - 20 °C

2: 97 percent / DMSO; (COCl)2; Et₃N / CH₂Cl₂ / -78 °C

With lithium borohydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In methanol; diethyl ether; dichloromethane; 2: Swern oxidation;
DOI:10.1055/s-2005-862361

Reference yield:

: 88099-67-6
methyl (2S)-2-(dibenzylamino)-3-hydroxypropanoate

: 125654-82-2
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-dibenzylamino-propionaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / imidazole / dimethylformamide / Ambient temperature

2: 84 percent / NaBH₄, LiCl / tetrahydrofuran; ethanol / Ambient temperature

3: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) from -78 deg C to room temperature, 45 min.

With 1H-imidazole; sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; triethylamine; lithium chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(98)00232-4

Reference yield:

: 100-39-0
benzyl bromide

: 125654-82-2
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-dibenzylamino-propionaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrahydrofuran; dimethyl sulfoxide / Reflux

2: 1H-imidazole / dichloromethane / 12 h / 50 °C

3: methanol; lithium borohydride / tetrahydrofuran; diethyl ether / 3 h / Reflux

4: dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane / 0 °C

With 1H-imidazole; methanol; lithium borohydride; sulfur trioxide pyridine complex; sodium hydrogencarbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; 4: |Parikh-Doering Oxidation;
DOI:10.1021/jacs.1c09616