3-cyclopentyl-2-phenylpropionic acid methyl ester

Base Information

• Chemical Name: 3-cyclopentyl-2-phenylpropionic acid methyl ester
• CAS No.: 933068-88-3
• Molecular Formula: C₁₅H₂₀O₂
• Molecular Weight: 232.323
• Mol file: 933068-88-3.mol

Synonyms:3-cyclopentyl-2-phenylpropionic acid methyl ester

Chemical Property of 3-cyclopentyl-2-phenylpropionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-cyclopentyl-2-phenylpropionic acid methyl ester

There total 2 articles about 3-cyclopentyl-2-phenylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclopentylmethyl Iodide (27935-87-1) + benzeneacetic acid methyl ester (101-41-7) → 3-cyclopentyl-2-phenylpropionic acid methyl ester (933068-88-3)

Guidance literature:

benzeneacetic acid methyl ester; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

cyclopentylmethyl Iodide; In tetrahydrofuran; at -78 - 25 ℃; Inert atmosphere;

DOI:10.1021/jm100039a

Reference yield:

cyclopentylmethyl trifluoromethanesulfonate (934266-79-2) → 3-cyclopentyl-2-phenylpropionic acid methyl ester (933068-88-3)

Guidance literature:

benzeneacetic acid methyl ester; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; phthalic acid dimethyl ester; at -78 ℃; for 0.916667 - 1.91667h;

cyclopentylmethyl trifluoromethanesulfonate; In tetrahydrofuran; hexane; phthalic acid dimethyl ester; at -78 - 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; hexane; phthalic acid dimethyl ester; water;

Reference yield: 62.0%

3-cyclopentyl-2-phenylpropionic acid methyl ester (933068-88-3) + N-Methylurea (598-50-5) → 1-(3-cyclopentyl-2-phenyl-propionyl)-3-methyl-urea (300354-51-2)

Guidance literature:

With magnesium methanolate; In methanol; at 120 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jm100039a

upstream raw materials:

cyclopentylmethyl trifluoromethanesulfonate

cyclopentylmethyl Iodide

benzeneacetic acid methyl ester

Downstream raw materials:

3-cyclopentyl-2-phenylpropionic acid

1-(3-cyclopentyl-2-phenyl-propionyl)-3-methyl-urea

Refernces

• 1、 -. "SULFONAMIDE DERIVATIVES AS GLYCOKINASE ACTIVATORS USEFUL IN THE TREATMENT OF TYPE 2 DIABETES". Page/Page column 39. . Retrieved 2008/06/13.