N,N'-[(1R)-4-Cyclohexene-1beta,2alpha-diyl]bis(carbamic acid tert-butyl) ester

Base Information

Chemical Name:N,N'-[(1R)-4-Cyclohexene-1beta,2alpha-diyl]bis(carbamic acid tert-butyl) ester
CAS No.:208533-46-4
Molecular Formula:C₁₆H₂₈N₂O₄
Molecular Weight:312.409
Hs Code.:
DSSTox Substance ID:DTXSID201135898
Nikkaji Number:J3.438.546G

Synonyms:SCHEMBL4270314;DTXSID201135898;208533-46-4;Carbamic acid, (1R,2R)-4-cyclohexene-1,2-diylbis-, bis(1,1-dimethylethyl) ester;N,N'-[(1R)-4-Cyclohexene-1beta,2alpha-diyl]bis(carbamic acid tert-butyl) ester

Suppliers and Price of N,N'-[(1R)-4-Cyclohexene-1beta,2alpha-diyl]bis(carbamic acid tert-butyl) ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N'-[(1R)-4-Cyclohexene-1beta,2alpha-diyl]bis(carbamic acid tert-butyl) ester

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:312.20490738
Heavy Atom Count:22
Complexity:392

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CC=CCC1NC(=O)OC(C)(C)C
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H]1CC=CC[C@H]1NC(=O)OC(C)(C)C

Technology Process of N,N'-[(1R)-4-Cyclohexene-1beta,2alpha-diyl]bis(carbamic acid tert-butyl) ester

There total 7 articles about N,N'-[(1R)-4-Cyclohexene-1beta,2alpha-diyl]bis(carbamic acid tert-butyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 2,3-Dihydroxy-succinic acid; compound with (1R,2R)-cyclohex-4-ene-1,2-diamine

: 208533-46-4
(1R,2R)-1,2-bis(N,N’-tert-butyloxycarbonylamino)-4-cyclohexene

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; Ambient temperature;
DOI:10.1002/(SICI)1099-1344(199805)41:5<443::AID-JLCR100>3.0.CO;2-W

Reference yield: 86.6%

: 24424-99-5
di-tert-butyl dicarbonate

: 1241684-26-3,208533-40-8
(1R,2R)-cyclohex-4-ene-1,2-diamine

: 208533-46-4
(1R,2R)-1,2-bis(N,N’-tert-butyloxycarbonylamino)-4-cyclohexene

Guidance literature:: In ethanol; for 1.5h;
DOI:10.1007/s00775-017-1502-z

Reference yield: 71.0%

: 24424-99-5
di-tert-butyl dicarbonate

: (1R,2R)-N,N'-bis[(S)-1-(4-methoxyphenyl)ethyl]cyclohex-4-ene-1,2-diamine

: 208533-46-4
(1R,2R)-1,2-bis(N,N’-tert-butyloxycarbonylamino)-4-cyclohexene

Guidance literature:: (1R,2R)-N,N'-bis[(S)-1-(4-methoxyphenyl)ethyl]cyclohex-4-ene-1,2-diamine; With boron trichloride; In dichloromethane; for 24h;

With sodium hydroxide; In dichloromethane; for 3h;

di-tert-butyl dicarbonate; In dichloromethane; for 12h;
DOI:10.1002/ejoc.201403058