N-(3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Base Information

Chemical Name:N-(3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
CAS No.:1227494-65-6
Molecular Formula:C₂₈H₃₀N₈O
Molecular Weight:494.599
Hs Code.:

Synonyms:N-(3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

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Chemical Property of N-(3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

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Technology Process of N-(3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

There total 3 articles about N-(3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1451042-78-6
4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[(4-oxo-2-pyrimidinyl)amino]-phenyl]benzamide

: 109299-78-7
pyrimidine 5-boronic acid

: 1227494-65-6
N-(3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Guidance literature:: 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[(4-oxo-2-pyrimidinyl)amino]-phenyl]benzamide; With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; at 45 ℃; for 1.5h; Inert atmosphere;

pyrimidine 5-boronic acid; With bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 20 ℃; for 1h; Inert atmosphere;

With sodium carbonate; In 1,4-dioxane; water; at 100 ℃; for 24h; Inert atmosphere;

Reference yield:

: 1025717-41-2
2-(2-methyl-5-nitrophenylamino)pyrimidin-4-one

: 1227494-65-6
N-(3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium chloride; hydrogenchloride; iron / ethanol; water / 3.5 h / 55 - 65 °C

2.1: tetrahydrofuran / 24 h / 20 °C

3.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / 1,4-dioxane / 1.5 h / 45 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

3.3: 24 h / 100 °C / Inert atmosphere

With hydrogenchloride; iron; ammonium chloride; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

: 1451042-77-5
2-(5-amino-2-methylphenylamino)pyrimidin-4-one

: 1227494-65-6
N-(3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 24 h / 20 °C

2.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / 1,4-dioxane / 1.5 h / 45 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

2.3: 24 h / 100 °C / Inert atmosphere

With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane;