8-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-methyl-2-(2-trifluoromethyl-phenyl)-7H-purine

Base Information

Chemical Name:8-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-methyl-2-(2-trifluoromethyl-phenyl)-7H-purine
CAS No.:1332875-06-5
Molecular Formula:C₂₁H₂₀ClF₃N₆
Molecular Weight:448.878
Hs Code.:

Synonyms:8-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-methyl-2-(2-trifluoromethyl-phenyl)-7H-purine

Suppliers and Price of 8-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-methyl-2-(2-trifluoromethyl-phenyl)-7H-purine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 8-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-methyl-2-(2-trifluoromethyl-phenyl)-7H-purine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-methyl-2-(2-trifluoromethyl-phenyl)-7H-purine

There total 8 articles about 8-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-methyl-2-(2-trifluoromethyl-phenyl)-7H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332875-04-3
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-methyl-5-nitro-2-(2-trifluoromethyl-phenyl)-pyrimidin-4-yl]-amide

: 1332875-06-5
8-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-methyl-2-(2-trifluoromethyl-phenyl)-7H-purine

Guidance literature:: 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-methyl-5-nitro-2-(2-trifluoromethyl-phenyl)-pyrimidin-4-yl]-amide; With iron; acetic acid; at 100 ℃; for 4h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1423-27-4
2-(trifluoromethyl)phenylboronic acid

: 1332875-06-5
8-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-methyl-2-(2-trifluoromethyl-phenyl)-7H-purine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

3: tetrahydrofuran; mineral oil / 0.25 h / 20 °C

4: iron / acetic acid / 4 h / 100 °C

With potassium phosphate; iron; sodium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In tetrahydrofuran; 1,4-dioxane; mineral oil; 1: Suzuki Coupling;

Reference yield:

: 5453-06-5
4-Amino-5-nitro-6-methyl-2-chloropyrimidine

: 1332875-06-5
8-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-methyl-2-(2-trifluoromethyl-phenyl)-7H-purine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

3: tetrahydrofuran; mineral oil / 0.25 h / 20 °C

4: iron / acetic acid / 4 h / 100 °C

With potassium phosphate; iron; sodium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In tetrahydrofuran; 1,4-dioxane; mineral oil; 1: Suzuki Coupling;