5453-06-5

Basic information

• Product Name: 4-AMINO-2-CHLORO-6-METHYL-5-NITROPYRIMIDINE
• Synonyms: IFLAB-BB F2124-0179;(2-chloro-6-methyl-5-nitro-pyrimidin-4-yl)amine;2-chloro-6-methyl-5-nitro-pyrimidin-4-amine;2-chloro-6-methyl-5-nitropyrimidin-4-amine;4-Amino-5-nitro-6-methyl-2-chloropyrimidine;NSC 19054;4-AMINO-2-CHLORO-6-METHYL-5-NITROPYRIMIDINE
• CAS NO: 5453-06-5
• Molecular Formula: C₅H₅ClN₄O₂
• Molecular Weight: 188.57
• Product Categories: Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides;Amines;Aromatics;Heterocycles
• Mol File: 5453-06-5.mol

Chemical Properties

• Melting Point: 166-170°C
• Boiling Point: 402.2°Cat760mmHg
• Flash Point: 197°C
• Appearance: /
• Density: 1.594g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: -20°C Freezer
• Solubility: Dichloromethane (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• Stability: Toxic
• CAS DataBase Reference: 4-AMINO-2-CHLORO-6-METHYL-5-NITROPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-CHLORO-6-METHYL-5-NITROPYRIMIDINE(5453-06-5)
• EPA Substance Registry System: 4-AMINO-2-CHLORO-6-METHYL-5-NITROPYRIMIDINE(5453-06-5)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 36/37
• Hazardous Substances Data: 5453-06-5(Hazardous Substances Data)

Usage

Chemical Properties

Orange Solid

InChI:InChI=1/C5H5ClN4O2/c1-2-3(10(11)12)4(7)9-5(6)8-2/h1H3,(H2,7,8,9)

Upstream product

• 13162-26-0 2,4-dichloro-6-methyl-5-nitropyrimidine 
• 7664-41-7 ammonia 

Downstream Products

• 1361569-93-8 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methyl-7,9-dihydro-8H-purin-8-one 
• 1361570-64-0 methyl {4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidin-5-yl}carbamate formate 
• 1361570-49-1 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methylpyrimidine-4,5-diamine 
• 1361570-48-0 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-methyl-5-nitropyrimidin-4-amine 
• 1332876-05-7 5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid [5-amino-6-methyl-2-(2-trifluoromethyl-phenyl)-pyrimidin-4-yl]-amide 
• 1332876-04-6 5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid [6-methyl-5-nitro-2-(2-trifluoromethyl-phenyl)-pyrimidin-4-yl]-amide 
• 1332875-04-3 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [6-methyl-5-nitro-2-(2-trifluoromethyl-phenyl)-pyrimidin-4-yl]-amide 
• 1332875-06-5 8-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-methyl-2-(2-trifluoromethyl-phenyl)-7H-purine 
• 1332875-05-4 6-methyl-5-nitro-2-(2-trifluoromethyl-phenyl)-pyrimidin-4-ylamine 
• 929623-90-5 6-methyl-5-nitro-N*2*-(4-trifluoromethylbenzyl)-pyrimidine-2,4-diamine 
• 2004-03-7 6-methylpurine 
• 1075-29-2 6-methyl-7,9-dihydro-purine-8-thione 
• 39209-57-9 6-methyl-7,9-dihydro-purin-8-one 
• 10179-83-6 7-methyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine 

Relevant articles and documents

SUBSTITUTED PURINE DERIVATIVE

The present invention relates to a substituted purine derivative of formula (1) wherein R1 is alkoxy or the like, R2 is alkyl or the like, Ring Q1 is aryl or the like, W1 is alkylene or the like, Ring Q2 is aromatic carbocyclyl or the like, n is 1 - 4, R3 is hydrogen atom or the like, X1 is single bond or the like, W2 is alkylene or the like, and R4 is hydrogen atom or the like, or a pharmaceutically acceptable salt thereof, which has a potent inhibitory effect against TLR7, and thereby is useful for treating autoimmune disease.