N-(4-bromo-5-methoxy-2-nitrophenyl)-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-(4-bromo-5-methoxy-2-nitrophenyl)-2,2,2-trifluoroacetamide
• CAS No.: 172535-87-4
• Molecular Formula: C₉H₆BrF₃N₂O₄
• Molecular Weight: 343.057
• Mol file: 172535-87-4.mol

Synonyms:N-(4-bromo-5-methoxy-2-nitrophenyl)-2,2,2-trifluoroacetamide

Chemical Property of N-(4-bromo-5-methoxy-2-nitrophenyl)-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-bromo-5-methoxy-2-nitrophenyl)-2,2,2-trifluoroacetamide

There total 5 articles about N-(4-bromo-5-methoxy-2-nitrophenyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-bromo-5-methoxy-2-nitrobenzeneamine (173312-36-2) + trifluoroacetic anhydride (407-25-0) → N-(4-bromo-5-methoxy-2-nitrophenyl)-2,2,2-trifluoroacetamide (172535-87-4)

Guidance literature:

With triethylamine; at 0 - 20 ℃; for 2h;

Reference yield:

1-bromo-2-methoxy-4-nitrobenzene (77337-82-7) → N-(4-bromo-5-methoxy-2-nitrophenyl)-2,2,2-trifluoroacetamide (172535-87-4)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 5percent Pd/C / ethyl acetate

3: KNO₃

With hydrogen; potassium nitrate; palladium on activated charcoal; In ethyl acetate;

DOI:10.1016/0040-4039(95)01562-V

Reference yield:

N-(4-Bromo-3-methoxy-phenyl)-2,2,2-trifluoro-acetamide → N-(4-bromo-5-methoxy-2-nitrophenyl)-2,2,2-trifluoroacetamide (172535-87-4)

Guidance literature:

With potassium nitrate;

DOI:10.1016/0040-4039(95)01562-V

upstream raw materials:

1-bromo-2-methoxy-4-nitrobenzene

4-bromo-3-methoxyaniline

4-bromo-5-methoxy-2-nitrobenzeneamine

trifluoroacetic anhydride

Downstream raw materials:

4-bromo-5-methoxy-2-nitrobenzeneamine

N-(4-Bromo-5-methoxy-2-nitro-phenyl)-oxalamic acid ethyl ester