(RS)-1-<2-amino-5-(benzyloxy)-4-methoxybenzyl>-2-methyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride

Base Information

Chemical Name:(RS)-1-<2-amino-5-(benzyloxy)-4-methoxybenzyl>-2-methyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride
CAS No.:131792-50-2
Molecular Formula:C₂₅H₂₈N₂O₂*2ClH
Molecular Weight:461.431
Hs Code.:

Synonyms:(RS)-1-<2-amino-5-(benzyloxy)-4-methoxybenzyl>-2-methyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride

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Chemical Property of (RS)-1-<2-amino-5-(benzyloxy)-4-methoxybenzyl>-2-methyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride

Chemical Property:

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Technology Process of (RS)-1-<2-amino-5-(benzyloxy)-4-methoxybenzyl>-2-methyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride

There total 5 articles about (RS)-1-<2-amino-5-(benzyloxy)-4-methoxybenzyl>-2-methyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 131792-49-9
1-<5-(benzyloxy)-4-methoxy-2-nitrobenzal>-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 131792-50-2
(RS)-1-<2-amino-5-(benzyloxy)-4-methoxybenzyl>-2-methyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; acetic acid; palladium on activated charcoal; under 2327.2 Torr;
DOI:10.1021/jm00107a030

Reference yield:

: 621-59-0
isovanillin

: 131792-50-2
(RS)-1-<2-amino-5-(benzyloxy)-4-methoxybenzyl>-2-methyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) hydrazine hydrate, 2.) KOH / 1.) reflux, 1 h, 2.) 120-140 deg C

2: 95 percent / K₂CO₃ / ethanol / Heating

3: 87 percent / concd. HNO₃, glacial AcOH / 2 h / 4 - 6 °C

4: 1.) Na, EtOH / 1.) from 50 deg C to 78 deg C, 2.) EtOH, reflux, 10 min

5: 56 percent / H₂, AcOH, concd. HCl / 10percent Pd/C / 2327.2 Torr

With hydrogenchloride; potassium hydroxide; ethanol; hydrogen; nitric acid; sodium; potassium carbonate; hydrazine hydrate; acetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00107a030

Reference yield:

: 1195-09-1
5-methyl-2-methoxyphenol

: 131792-50-2
(RS)-1-<2-amino-5-(benzyloxy)-4-methoxybenzyl>-2-methyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / K₂CO₃ / ethanol / Heating

2: 87 percent / concd. HNO₃, glacial AcOH / 2 h / 4 - 6 °C

3: 1.) Na, EtOH / 1.) from 50 deg C to 78 deg C, 2.) EtOH, reflux, 10 min

4: 56 percent / H₂, AcOH, concd. HCl / 10percent Pd/C / 2327.2 Torr

With hydrogenchloride; ethanol; hydrogen; nitric acid; sodium; potassium carbonate; acetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00107a030