Technology Process of (RS)-9-(benzyloxy)-10-methoxyaporphine hydrochloride
There total 6 articles about (RS)-9-(benzyloxy)-10-methoxyaporphine hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) hydrazine hydrate, 2.) KOH / 1.) reflux, 1 h, 2.) 120-140 deg C
2: 95 percent / K2CO3 / ethanol / Heating
3: 87 percent / concd. HNO3, glacial AcOH / 2 h / 4 - 6 °C
4: 1.) Na, EtOH / 1.) from 50 deg C to 78 deg C, 2.) EtOH, reflux, 10 min
5: 56 percent / H2, AcOH, concd. HCl / 10percent Pd/C / 2327.2 Torr
6: 1.) NaNO2, 10percent H2SO4, 2.) Cu / 1.) -5 deg C, 15 min, 2.) RT, 18 h
With
hydrogenchloride; potassium hydroxide; ethanol; sulfuric acid; hydrogen; nitric acid; sodium; copper; potassium carbonate; hydrazine hydrate; acetic acid; sodium nitrite;
palladium on activated charcoal;
In
ethanol;
DOI:10.1021/jm00107a030
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / K2CO3 / ethanol / Heating
2: 87 percent / concd. HNO3, glacial AcOH / 2 h / 4 - 6 °C
3: 1.) Na, EtOH / 1.) from 50 deg C to 78 deg C, 2.) EtOH, reflux, 10 min
4: 56 percent / H2, AcOH, concd. HCl / 10percent Pd/C / 2327.2 Torr
5: 1.) NaNO2, 10percent H2SO4, 2.) Cu / 1.) -5 deg C, 15 min, 2.) RT, 18 h
With
hydrogenchloride; ethanol; sulfuric acid; hydrogen; nitric acid; sodium; copper; potassium carbonate; acetic acid; sodium nitrite;
palladium on activated charcoal;
In
ethanol;
DOI:10.1021/jm00107a030
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 87 percent / concd. HNO3, glacial AcOH / 2 h / 4 - 6 °C
2: 1.) Na, EtOH / 1.) from 50 deg C to 78 deg C, 2.) EtOH, reflux, 10 min
3: 56 percent / H2, AcOH, concd. HCl / 10percent Pd/C / 2327.2 Torr
4: 1.) NaNO2, 10percent H2SO4, 2.) Cu / 1.) -5 deg C, 15 min, 2.) RT, 18 h
With
hydrogenchloride; ethanol; sulfuric acid; hydrogen; nitric acid; sodium; copper; acetic acid; sodium nitrite;
palladium on activated charcoal;
DOI:10.1021/jm00107a030
