2,6-difluoro-N-(5-(1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

Base Information

Chemical Name:2,6-difluoro-N-(5-(1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-yl)thiophen-2-yl)benzamide
CAS No.:1599475-10-1
Molecular Formula:C₂₀H₁₄F₂N₄OS
Molecular Weight:396.42
Hs Code.:

Synonyms:2,6-difluoro-N-(5-(1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

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Chemical Property of 2,6-difluoro-N-(5-(1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

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Technology Process of 2,6-difluoro-N-(5-(1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

There total 5 articles about 2,6-difluoro-N-(5-(1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-yl)thiophen-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1599475-33-8
C₁₃H₁₂N₄S

: 18063-02-0
2,6-difluorobenzoylchloride

: 1599475-10-1
2,6-difluoro-N-(5-(1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

Guidance literature:: C₁₃H₁₂N₄S; 2,6-difluorobenzoylchloride; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

With water; sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

: 1599475-31-6
C₉H₁₀BN₃O₂

: 1599475-10-1
2,6-difluoro-N-(5-(1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

2: hydrogen; palladium on activated charcoal / methanol

3: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With dmap; potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;

Reference yield:

: 1599475-32-7
C₁₃H₁₀N₄O₂S

: 1599475-10-1
2,6-difluoro-N-(5-(1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-yl)thiophen-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal / methanol

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With dmap; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;