(1R,2R,3S,4S,6R)-4-(4-chIoro-3-((4-cyclopropylphenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-triol

Base Information

Chemical Name:(1R,2R,3S,4S,6R)-4-(4-chIoro-3-((4-cyclopropylphenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-triol
CAS No.:1204222-23-0
Molecular Formula:C₂₃H₂₇ClO₄
Molecular Weight:404.902
Hs Code.:

Synonyms:(1R,2R,3S,4S,6R)-4-(4-chIoro-3-((4-cyclopropylphenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-triol

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Chemical Property of (1R,2R,3S,4S,6R)-4-(4-chIoro-3-((4-cyclopropylphenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-triol

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Technology Process of (1R,2R,3S,4S,6R)-4-(4-chIoro-3-((4-cyclopropylphenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-triol

There total 6 articles about (1R,2R,3S,4S,6R)-4-(4-chIoro-3-((4-cyclopropylphenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1204222-21-8
((1R,2S,3S,6R)-6-(benzyloxymethyl)-4-(4-chloro-3-((4-cyclopropylphenyl)methyl-d2)phenyl)cyclohex-4-ene-1,2,3-triyl)tris(oxy)tris(methylene)tribenzene

: 1204222-23-0
(1R,2R,3S,4S,6R)-4-(4-chIoro-3-((4-cyclopropylphenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-triol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; for 1.5h;

Reference yield:

: 1204220-77-8
4-bromo-1-chloro-2-(4-cyclopropylbenzyl)benzene

: 1204222-23-0
(1R,2R,3S,4S,6R)-4-(4-chIoro-3-((4-cyclopropylphenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-triol

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutylammonium bisulfate; water-d2; sodium hydride / hexane / 0 - 25 °C

1.2: 0 - 20 °C

2.1: magnesium; ethylene dibromide / tetrahydrofuran / Reflux; Inert atmosphere

2.2: 3 h / 25 °C / Inert atmosphere

3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / -25 °C

4.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 1.5 h

With triethylsilane; tetrabutylammonium bisulfate; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; water-d2; sodium hydride; magnesium; ethylene dibromide; In tetrahydrofuran; methanol; hexane; dichloromethane;

Reference yield:

: 1204220-70-1
(5-bromo-2-chlorophenyl)(4-cyclopropylphenyl)methanone

: 1204222-23-0
(1R,2R,3S,4S,6R)-4-(4-chIoro-3-((4-cyclopropylphenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-triol

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃SiD; trifluorormethanesulfonic acid; trifluoroacetic acid / tetrahydrofuran / 2 h / 25 °C

2.1: magnesium; ethylene dibromide / tetrahydrofuran / Reflux; Inert atmosphere

2.2: 3 h / 25 °C / Inert atmosphere

3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / -25 °C

4.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 1.5 h

With triethylsilane; Et₃SiD; trifluorormethanesulfonic acid; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; magnesium; ethylene dibromide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;