dimethyl (1'E,3'S)-2-(3'-acetoxy-4'-t-butyldiphenylsilyloxy-but-1'-enyl)-2-benzylmalonate

Base Information

Chemical Name:dimethyl (1'E,3'S)-2-(3'-acetoxy-4'-t-butyldiphenylsilyloxy-but-1'-enyl)-2-benzylmalonate
CAS No.:342909-14-2
Molecular Formula:C₃₄H₄₀O₇Si
Molecular Weight:588.773
Hs Code.:

Synonyms:dimethyl (1'E,3'S)-2-(3'-acetoxy-4'-t-butyldiphenylsilyloxy-but-1'-enyl)-2-benzylmalonate

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Chemical Property of dimethyl (1'E,3'S)-2-(3'-acetoxy-4'-t-butyldiphenylsilyloxy-but-1'-enyl)-2-benzylmalonate

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Technology Process of dimethyl (1'E,3'S)-2-(3'-acetoxy-4'-t-butyldiphenylsilyloxy-but-1'-enyl)-2-benzylmalonate

There total 2 articles about dimethyl (1'E,3'S)-2-(3'-acetoxy-4'-t-butyldiphenylsilyloxy-but-1'-enyl)-2-benzylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 342906-84-7
dimethyl (2'E,1'R)-2-[1'-acetoxy-4'-(t-butyldiphenylsilyloxy)-2'-butenyl]-2-benzylmalonate

: 342909-14-2
dimethyl (1'E,3'S)-2-(3'-acetoxy-4'-t-butyldiphenylsilyloxy-but-1'-enyl)-2-benzylmalonate

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); In toluene; at 110 ℃; for 12h;
DOI:10.1021/ja003775g

Reference yield:

: 169689-20-7
(E)-1,1-diacetoxy-4-(t-butyldiphenylsilyloxy)-2-butene

: 342909-14-2
dimethyl (1'E,3'S)-2-(3'-acetoxy-4'-t-butyldiphenylsilyloxy-but-1'-enyl)-2-benzylmalonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 20 °C

1.2: π-palladium chloride dimer; (R,R)-1,2-di(2'-diphenylphosphinobenzamido)cyclohexane / tetrahydrofuran / 3 h / 0 °C

2.1: Pd(CH₃CN)2Cl₂ / toluene / 12 h / 110 °C

With dichloro bis(acetonitrile) palladium(II); sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1021/ja003775g