2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenylcarbamic acid methyl ester

Base Information

• Chemical Name: 2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenylcarbamic acid methyl ester
• CAS No.: 273735-80-1
• Molecular Formula: C₁₂H₁₀F₇NO₂
• Molecular Weight: 333.206
• Mol file: 273735-80-1.mol

Synonyms:2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenylcarbamic acid methyl ester

Chemical Property of 2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenylcarbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenylcarbamic acid methyl ester

There total 2 articles about 2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenylcarbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-methyl-4-(heptafluoropropan-2-yl)-aniline (238098-26-5) + methyl chloroformate (79-22-1) → 2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenylcarbamic acid methyl ester (273735-80-1)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 10 - 20 ℃; for 4h; Product distribution / selectivity;

Reference yield:

→ 2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenylcarbamic acid methyl ester (273735-80-1)

Guidance literature:

Reference yield: 91.3%

2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenylcarbamic acid methyl ester (273735-80-1) + acetic anhydride (108-24-7) → methyl acetyl(2-methyl-4-(perfluoropropan-2-yl)phenyl)carbamate

Guidance literature:

2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenylcarbamic acid methyl ester; With sodium methylate; In toluene; for 0.5h; Reflux;

acetic anhydride; In toluene; for 4h; Reflux;

upstream raw materials:

2-methyl-4-(heptafluoropropan-2-yl)-aniline

methyl chloroformate

Downstream raw materials:

methyl (2-(chloromethyl)-4-(perfluoropropane-2-yl)phenyl)carbamate