C₂₁H₂₆O₄

Base Information

• Chemical Name: C₂₁H₂₆O₄
• CAS No.: 1302981-89-0
• Molecular Formula: C₂₁H₂₆O₄
• Molecular Weight: 342.435
• Mol file: 1302981-89-0.mol

Synonyms:C₂₁H₂₆O₄

Chemical Property of C₂₁H₂₆O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₆O₄

There total 1 articles about C₂₁H₂₆O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C18H22O2 (1302981-88-9) + chloroformic acid ethyl ester (541-41-3) → C21H26O4 (1302981-89-0)

Guidance literature:

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2010.11.012

Reference yield: 68.0%

C21H26O4 (1302981-89-0) + lithium dimethylcuprate (15681-48-8) → C22H30O4 (1302981-90-3)

Guidance literature:

C₂₁H₂₆O₄; lithium dimethylcuprate; In tetrahydrofuran; at -78 ℃;

With methanol; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/j.tetlet.2010.11.012

Reference yield:

C21H26O4 (1302981-89-0) → C21H29NO2 (1302981-70-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrahydrofuran / -78 °C

1.2: -78 °C

2.1: diisobutylaluminium hydride / -78 °C

3.1: chloro-trimethyl-silane; tetrabutyl ammonium fluoride; triethylamine / tetrahydrofuran

4.1: 2,6-di-tert-butyl-4-methyl-phenol / toluene / 16 h / 90 °C / Inert atmosphere

5.1: hydrogenchloride; water; zinc / methanol

With hydrogenchloride; chloro-trimethyl-silane; 2,6-di-tert-butyl-4-methyl-phenol; tetrabutyl ammonium fluoride; water; diisobutylaluminium hydride; triethylamine; zinc; In tetrahydrofuran; methanol; toluene; 3.1: Henry reaction / 4.1: Intramolecular Diels-Alder reaction;

DOI:10.1016/j.tetlet.2010.11.012

upstream raw materials:

C₁₈H₂₂O₂

chloroformic acid ethyl ester

Downstream raw materials:

C₂₁H₂₉NO₂

C₂₁H₂₇NO₄

C₂₀H₂₆O₃

(1S,4aS,5S,8aR)-1-(((4-methoxybenzyl)oxy)methyl)-1,3-dimethyl-5-nitro-1,2,4a,5,6,8a-hexahydronaphthalene