(1R)-1-<(2R)-2-benzenesulfonyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-(1S)-1-methyl-cyclobutyl>-ethanol

Base Information

Chemical Name:(1R)-1-<(2R)-2-benzenesulfonyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-(1S)-1-methyl-cyclobutyl>-ethanol
CAS No.:165544-81-0
Molecular Formula:C₃₀H₃₈O₄SSi
Molecular Weight:522.781
Hs Code.:

Synonyms:(1R)-1-<(2R)-2-benzenesulfonyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-(1S)-1-methyl-cyclobutyl>-ethanol

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Chemical Property of (1R)-1-<(2R)-2-benzenesulfonyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-(1S)-1-methyl-cyclobutyl>-ethanol

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Technology Process of (1R)-1-<(2R)-2-benzenesulfonyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-(1S)-1-methyl-cyclobutyl>-ethanol

There total 1 articles about (1R)-1-<(2R)-2-benzenesulfonyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-(1S)-1-methyl-cyclobutyl>-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 165544-80-9
(1R)-1-<(2S)-2-benzenesulfonyl-2-hydroxymethyl-(1R)-1-methyl-cyclobutyl>-ethanol

: 165544-81-0
(1R)-1-<(2R)-2-benzenesulfonyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-(1S)-1-methyl-cyclobutyl>-ethanol

Guidance literature:: With 1H-imidazole; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1016/0957-4166(95)00141-B

Reference yield: 91.0%

: 124-63-0
methanesulfonyl chloride

: 165544-81-0
(1R)-1-<(2R)-2-benzenesulfonyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-(1S)-1-methyl-cyclobutyl>-ethanol

: 165544-82-1
(1R)-1-<(2R)-2-benzenesulfonyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-(1S)-1-methyl-cyclobutyl>-ethyl methanesulfonate

Guidance literature:: With pyridine; at 40 ℃; for 3h;
DOI:10.1016/0957-4166(95)00141-B

Reference yield:

: 165544-81-0
(1R)-1-<(2R)-2-benzenesulfonyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-(1S)-1-methyl-cyclobutyl>-ethanol

: 26532-22-9
(1R, 2S)-grandisol

Guidance literature:: Multi-step reaction with 11 steps

1: 91 percent / pyridine / 3 h / 40 °C

2: 76 percent / DBU / 5 h / 120 °C

3: 1.) BH₃*SMe₂, 2.) H₂O₂, aq. NaOH / 1.) THF, from 0 deg C to RT, 12 h, 2.) THF, from 0 deg C to RT, 0.5 h

4: 87 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 6 h / Ambient temperature

5: 85 percent / Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

6: pyridinium chlorochromate, 3A molecular sieves, NaOAc / CH₂Cl₂ / 3 h / Ambient temperature

7: tetrahydrofuran / 2 h / -20 °C

8: 92 percent / pyridinium chlorochromate, 3A molecular sieves, NaOAc / CH₂Cl₂ / 3 h / Ambient temperature

9: 92 percent / Na₂HPO₄, 6percent Hg(Na) / tetrahydrofuran; methanol / 3 h / -40 °C

10: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 1 h, 2.) THF, hexane, from 0 deg C to RT, 2 h

11: 41 percent / Dowex 50Wx₈ / methanol / 0.25 h / Ambient temperature

With pyridine; sodium hydroxide; disodium hydrogenphosphate; n-butyllithium; dowex 50Wx₈; dimethylsulfide borane complex; 3 A molecular sieve; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium acetate; sodium; pyridinium p-toluenesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; pyridinium chlorochromate; mercury; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0957-4166(95)00141-B