N-(6-(4-(1-ethoxy-2,2,2-trifluoroethylamino)-2-fluorophenoxy)pyrimidin-4-yl)pyrrolidine-1-carboxamide

Base Information

Chemical Name:N-(6-(4-(1-ethoxy-2,2,2-trifluoroethylamino)-2-fluorophenoxy)pyrimidin-4-yl)pyrrolidine-1-carboxamide
CAS No.:1020536-42-8
Molecular Formula:C₁₉H₂₁F₄N₅O₃
Molecular Weight:443.401
Hs Code.:

Synonyms:N-(6-(4-(1-ethoxy-2,2,2-trifluoroethylamino)-2-fluorophenoxy)pyrimidin-4-yl)pyrrolidine-1-carboxamide

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Chemical Property of N-(6-(4-(1-ethoxy-2,2,2-trifluoroethylamino)-2-fluorophenoxy)pyrimidin-4-yl)pyrrolidine-1-carboxamide

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Technology Process of N-(6-(4-(1-ethoxy-2,2,2-trifluoroethylamino)-2-fluorophenoxy)pyrimidin-4-yl)pyrrolidine-1-carboxamide

There total 1 articles about N-(6-(4-(1-ethoxy-2,2,2-trifluoroethylamino)-2-fluorophenoxy)pyrimidin-4-yl)pyrrolidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 864245-40-9
pyrrolidine-1-carboxylic acid [6-(4-amino-2-fluorophenoxy)pyrimidin-4-yl]amide

: 433-27-2
ethyl trifluoroacetaldehyde hemiacetal

: 1020536-42-8
N-(6-(4-(1-ethoxy-2,2,2-trifluoroethylamino)-2-fluorophenoxy)pyrimidin-4-yl)pyrrolidine-1-carboxamide

Guidance literature:: With toluene-4-sulfonic acid; In ethanol; for 24h; Heating / reflux;

Reference yield: 22.0%

: 1020536-42-8
N-(6-(4-(1-ethoxy-2,2,2-trifluoroethylamino)-2-fluorophenoxy)pyrimidin-4-yl)pyrrolidine-1-carboxamide

: 105-53-3
diethyl malonate

: 1020536-43-9
diethyl 2-(2,2,2-trifluoro-1-(3-fluoro-4-(6-(pyrrolidine-1-carboxamido)pyrimidin-4-yloxy)phenylamino)ethyl)malonate

Guidance literature:: N-(6-(4-(1-ethoxy-2,2,2-trifluoroethylamino)-2-fluorophenoxy)pyrimidin-4-yl)pyrrolidine-1-carboxamide; diethyl malonate; With sodium hydride; In tetrahydrofuran; for 5h; Heating / reflux;

With hydrogenchloride; water; In tetrahydrofuran; pH=3;