6-{(1E,3S,5S,6S,7E,9E,11E)-[13-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1,3,5,11-tetramethyltrideca-1,7,9,11-tetraen-1-yl]}-2,2-dimethyl-4H-1,3-dioxen-4-one

Base Information

• Chemical Name: 6-{(1E,3S,5S,6S,7E,9E,11E)-[13-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1,3,5,11-tetramethyltrideca-1,7,9,11-tetraen-1-yl]}-2,2-dimethyl-4H-1,3-dioxen-4-one
• CAS No.: 910042-96-5
• Molecular Formula: C₃₃H₄₆O₇
• Molecular Weight: 554.724

Synonyms:6-{(1E,3S,5S,6S,7E,9E,11E)-[13-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1,3,5,11-tetramethyltrideca-1,7,9,11-tetraen-1-yl]}-2,2-dimethyl-4H-1,3-dioxen-4-one

Chemical Property of 6-{(1E,3S,5S,6S,7E,9E,11E)-[13-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1,3,5,11-tetramethyltrideca-1,7,9,11-tetraen-1-yl]}-2,2-dimethyl-4H-1,3-dioxen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-{(1E,3S,5S,6S,7E,9E,11E)-[13-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1,3,5,11-tetramethyltrideca-1,7,9,11-tetraen-1-yl]}-2,2-dimethyl-4H-1,3-dioxen-4-one

There total 18 articles about 6-{(1E,3S,5S,6S,7E,9E,11E)-[13-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1,3,5,11-tetramethyltrideca-1,7,9,11-tetraen-1-yl]}-2,2-dimethyl-4H-1,3-dioxen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl [6-(tert-butyldiphenylsilyloxy)-3(S),5(S)-dimethyl-2(S)-(methoxymethoxy)hex-1-yl] ether (136786-39-5) → 6-{(1E,3S,5S,6S,7E,9E,11E)-[13-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1,3,5,11-tetramethyltrideca-1,7,9,11-tetraen-1-yl]}-2,2-dimethyl-4H-1,3-dioxen-4-one (910042-96-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 86 percent / hydrogen / Pd/C / ethanol / 760 Torr

2.1: 100 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 0.67 h / -78 - 20 °C

3.1: HMPA; nBuLi / tetrahydrofuran; petroleum ether / 0.17 h / cooling

3.2: 92 percent / tetrahydrofuran; petroleum ether / 1.17 h / -78 - 20 °C

4.1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C

5.1: 100 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

6.1: LDA / tetrahydrofuran; petroleum ether / -78 - 0 °C

6.2: 78 percent / HMPA / tetrahydrofuran; petroleum ether / -78 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; Petroleum ether; 2.1: Swern oxidation / 3.2: Horner-Wadsworth-Emmons olefination / 5.1: Swern oxidation / 6.2: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/ja0581346

Reference yield:

(2S,3S,5S)-1-(benzyloxy)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexan-2-ol (136786-36-2) → 6-{(1E,3S,5S,6S,7E,9E,11E)-[13-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1,3,5,11-tetramethyltrideca-1,7,9,11-tetraen-1-yl]}-2,2-dimethyl-4H-1,3-dioxen-4-one (910042-96-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 89 percent / iPr₂NEt; TBAI / CH₂Cl₂ / 48 h / 20 °C

2.1: 86 percent / hydrogen / Pd/C / ethanol / 760 Torr

3.1: 100 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 0.67 h / -78 - 20 °C

4.1: HMPA; nBuLi / tetrahydrofuran; petroleum ether / 0.17 h / cooling

4.2: 92 percent / tetrahydrofuran; petroleum ether / 1.17 h / -78 - 20 °C

5.1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C

6.1: 100 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

7.1: LDA / tetrahydrofuran; petroleum ether / -78 - 0 °C

7.2: 78 percent / HMPA / tetrahydrofuran; petroleum ether / -78 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; tetra-(n-butyl)ammonium iodide; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; Petroleum ether; 3.1: Swern oxidation / 4.2: Horner-Wadsworth-Emmons olefination / 6.1: Swern oxidation / 7.2: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/ja0581346

Reference yield:

(2S,4E)-6-[(4-methoxyphenyl)methoxy]-2-methylhex-4-en-1-ol (910043-29-7) → 6-{(1E,3S,5S,6S,7E,9E,11E)-[13-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1,3,5,11-tetramethyltrideca-1,7,9,11-tetraen-1-yl]}-2,2-dimethyl-4H-1,3-dioxen-4-one (910042-96-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: imidazole / dimethylformamide / 15 h / 20 °C

1.2: DDQ; water / CH₂Cl₂ / 0.25 h / 20 °C

1.3: 72 percent / NaBH₄ / CH₂Cl₂ / 24 h / 20 °C

2.1: (-)-DET; tBuOOH; 4A MS / Ti(OiPr)4 / CH₂Cl₂ / 24 h / -40 - -23 °C

2.2: 2.42 g / KH; TBAI / tetrahydrofuran / 0.75 h / 0 - 20 °C

3.1: 78 percent / nBuLi / petroleum ether / 3 h / -30 - 0 °C

4.1: 89 percent / iPr₂NEt; TBAI / CH₂Cl₂ / 48 h / 20 °C

5.1: 86 percent / hydrogen / Pd/C / ethanol / 760 Torr

6.1: 100 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 0.67 h / -78 - 20 °C

7.1: HMPA; nBuLi / tetrahydrofuran; petroleum ether / 0.17 h / cooling

7.2: 92 percent / tetrahydrofuran; petroleum ether / 1.17 h / -78 - 20 °C

8.1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C

9.1: 100 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

10.1: LDA / tetrahydrofuran; petroleum ether / -78 - 0 °C

10.2: 78 percent / HMPA / tetrahydrofuran; petroleum ether / -78 - 20 °C

With 1H-imidazole; tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; tetra-(n-butyl)ammonium iodide; dimethyl sulfoxide; (-)-diethyl tartrate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; titanium(IV) isopropylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; Petroleum ether; 6.1: Swern oxidation / 7.2: Horner-Wadsworth-Emmons olefination / 9.1: Swern oxidation / 10.2: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/ja0581346

upstream raw materials:

(2S,4E)-6-[(4-methoxyphenyl)methoxy]-2-methylhex-4-en-1-ol

(2E,4E)-1-chloro-6-[(4-methoxyphenyl)methoxy]-4-methylhexa-2,4-diene

(2E,4E)-6-[(4-methoxyphenyl)methoxy]-4-methylhexa-2,4-dien-1-ol

(E)-6-[(4-methoxyphenyl)methoxy]-4-methylhex-4-en-2-yn-1-ol

Downstream raw materials:

C₆₂H₈₄O₁₃Si

1-(3-{(1S,2S,4aS,5S,6S,8S,8aR)-2-[(E)-3-(4-Methoxy-benzyloxy)-1-methyl-propenyl]-5-methoxymethoxy-1,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-oxo-propionyloxy)-cyclohexanecarboxylic acid methyl ester

3-{(1S,2S,4aS,5S,6S,8S,8aR)-2-[(E)-3-(4-Methoxy-benzyloxy)-1-methyl-propenyl]-5-methoxymethoxy-1,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-oxo-propionic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 910042-96-5 6-{(1E,3S,5S,6S,7E,9E,11E)-[13-(4-methoxybenzyloxy)-6-(methoxymethoxy)-1,3,5,11-tetramethyltrideca-1,7,9,11-tetraen-1-yl]}-2,2-dimethyl-4H-1,3-dioxen-4-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send